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BCR affinity differ...
BCR affinity differentially regulates colonization of the subepithelial dome and infiltration into germinal centers within Peyer's patches.
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Biram, Adi (author)
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- Strömberg, Anneli, 1979 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology
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Winter, Eitan (author)
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Stoler-Barak, Liat (author)
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Salomon, Ran (author)
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Addadi, Yoseph (author)
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Dahan, Rony (author)
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Yaari, Gur (author)
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- Bemark, Mats, 1967 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology
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Shulman, Ziv (author)
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(creator_code:org_t)
- 2019-03-04
- 2019
- English.
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In: Nature immunology. - : Springer Science and Business Media LLC. - 1529-2916 .- 1529-2908. ; 20:4, s. 482-492
- Related links:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Gut-derived antigens trigger immunoglobulin A (IgA) immune responses that are initiated by cognate B cells in Peyer's patches (PPs). These cells colonize the subepithelial domes (SEDs) of the PPs and subsequently infiltrate pre-existing germinal centers (GCs). Here we defined the pre-GC events and the micro-anatomical site at which affinity-based B cell selection occurred in PPs. Using whole-organ imaging, we showed that the affinity of the B cell antigen receptor (BCR) regulated the infiltration of antigen-specific B cells into GCs but not clonal competition in the SED. Follicular helper-like T cells resided in the SED and promoted its B cell colonization, independently of the magnitude of BCR affinity. Imaging and immunoglobulin sequencing indicated that selective clonal expansion ensued during infiltration into GCs. Thus, in contrast to the events in draining lymph nodes and spleen, in PPs, T cells promoted mainly the population expansion of B cells without clonal selection during pre-GC events. These findings have major implications for the design of oral vaccines.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- IgA
- Peyer´s patches
- B cell activation
- germinal center
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Biram, Adi
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Strömberg, Annel ...
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Winter, Eitan
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Stoler-Barak, Li ...
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Salomon, Ran
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Addadi, Yoseph
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show more...
-
Dahan, Rony
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Yaari, Gur
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Bemark, Mats, 19 ...
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Shulman, Ziv
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
- Articles in the publication
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Nature immunolog ...
- By the university
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University of Gothenburg