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Characterization of...
Characterization of sensitization to furry animal allergen components in an adult population.
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- Suzuki, Shintaro (author)
- Gothenburg University,Göteborgs universitet,Krefting Research Centre,Univ Gothenburg, Sahlgrenska Acad, Inst Med, Krefting Res Ctr, Gothenburg, Sweden; Showa Univ, Sch Med, Dept Med, Div Allergol & Resp Med, Tokyo, Japan
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- Nwaru, Bright I, 1978 (author)
- Gothenburg University,Göteborgs universitet,Krefting Research Centre,Univ Gothenburg, Sahlgrenska Acad, Inst Med, Krefting Res Ctr, Gothenburg, Sweden; Univ Gothenburg, Inst Med, Wallenberg Ctr Mol & Translat Med, Gothenburg, Sweden
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- Ekerljung, Linda, 1979 (author)
- Gothenburg University,Göteborgs universitet,Krefting Research Centre,Univ Gothenburg, Sahlgrenska Acad, Inst Med, Krefting Res Ctr, Gothenburg, Sweden
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- Sjölander, Sigrid (author)
- Thermo Fisher Sci, ImmunoDiagnost, Uppsala, Sweden
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- Mincheva, Roxana, 1986 (author)
- Gothenburg University,Göteborgs universitet,Krefting Research Centre,Univ Gothenburg, Sahlgrenska Acad, Inst Med, Krefting Res Ctr, Gothenburg, Sweden
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- Rönmark, Erik P, 1981 (author)
- Gothenburg University,Göteborgs universitet,Krefting Research Centre,Univ Gothenburg, Sahlgrenska Acad, Inst Med, Krefting Res Ctr, Gothenburg, Sweden
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- Rönmark, Eva, 1953 (author)
- Umeå universitet,Yrkes- och miljömedicin,Umeå Univ, OLIN Unit, Dept Publ Hlth & Clin Med, Occupat & Environm Med, Umeå, Sweden
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- Lundbäck, Bo, 1948 (author)
- Gothenburg University,Göteborgs universitet,Krefting Research Centre,Univ Gothenburg, Sahlgrenska Acad, Inst Med, Krefting Res Ctr, Gothenburg, Sweden
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- Borres, Magnus P., 1956 (author)
- Uppsala universitet,Pediatrisk inflammationsforskning,Thermo Fisher Sci, ImmunoDiagnost, Uppsala, Sweden
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- Lötvall, Jan, 1956 (author)
- Gothenburg University,Göteborgs universitet,Krefting Research Centre,Univ Gothenburg, Sahlgrenska Acad, Inst Med, Krefting Res Ctr, Gothenburg, Sweden
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(creator_code:org_t)
- 2019-02-27
- 2019
- English.
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In: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. - : Wiley. - 1365-2222 .- 0954-7894. ; 49:4, s. 495-505
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Abstract
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- There are paucity of data on sensitization to furry animal allergen components in adults. Furry animals are major sensitizers and contributors to asthma burden in northern Europe and North America.To characterize sensitization patterns to furry animal allergen components in Swedish adults.Based on the West Sweden Asthma Study, a random population (n=1103) and an asthma sample (n=769) were tested for allergen sensitization using Phadiatop® . Those with IgE≥0.35kUA /L were tested for cat (Fel d 1, 2, and 4), dog (Can f 1, 2, 3, and 5), and horse (Equ c 1) allergen component sensitization. We defined allergen component poly-sensitization patterns, identified data-driven sensitization clusters, described component sensitization overlaps, and assessed determinants of sensitization patterns.The prevalence of allergen component sensitization ranged from 0.8% for Fel d 2 and Can f 3 to 8.9% for Fel d 1. The most common dog component was Can f 5 (3.6%); 2.1% were sensitized to Equ c 1. Those sensitized to Fel d 2 and Fel d 4 were commonly sensitized to Fel d 1. The most common dog component overlap was between Can f 1/Can f 2 and Can f 5. Mono-sensitization was 5.6%, double sensitization 1.5% and poly-sensitization 2.1%. Sensitization was always higher in the asthma than in the random sample. Three sensitization clusters were derived, namely non-sensitized (90% in random vs 66% in asthma sample); Fel d 1-driven sensitized (7% vs 19%); and multi-sensitized (3% vs 15%). Key determinants of sensitization were gender, age, raised on a farm, family history of allergy or asthma, smoking, and occupational exposure to dust or fumes.Fel d 1 and Can f 5 are the most common cat and dog components sensitization in this adult Swedish population. Mono-sensitization is more common than poly-sensitization. This detailed characterization highlights the current distribution of furry animal allergen components in Swedish adults, and their impact on clinical outcomes of asthma will be further explored.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
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- ref (subject category)
- art (subject category)
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Suzuki, Shintaro
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Nwaru, Bright I, ...
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Ekerljung, Linda ...
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Sjölander, Sigri ...
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Mincheva, Roxana ...
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Rönmark, Erik P, ...
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Rönmark, Eva, 19 ...
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Lundbäck, Bo, 19 ...
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Borres, Magnus P ...
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Lötvall, Jan, 19 ...
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University of Gothenburg
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Umeå University
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Uppsala University