Search: onr:"swepub:oai:gup.ub.gu.se/280729" >
Risk Factors for hy...
Risk Factors for hypospadias in Northwest Russia: A Murmansk County Birth Registry Study
-
- Kovalenko, A. A. (author)
- Department of Community Medicine, UiT -The Arctic University of Norway, Tromsø, Norway / International School of Public Health, Northern State Medical University, Arkhangelsk, Russia
-
- Brenn, T. (author)
- Department of Community Medicine, UiT -The Arctic University of Norway, Tromsø, Norway
-
- Odland, J. O. (author)
- Department of Community Medicine, UiT -The Arctic University of Norway, Tromsø, Norway
-
show more...
-
- Nieboer, E. (author)
- Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada
-
- Krettek, Alexandra, 1968 (author)
- Högskolan i Skövde,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Institutionen för hälsa och lärande,Forskningsspecialiseringen Hälsa och Lärande,Department of Community Medicine, UiT -The Arctic University of Norway, Tromsø, Norway / Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden,Individ och samhälle, Individual and Society (VIDSOC)
-
- Anda, E. E. (author)
- Department of Community Medicine, UiT -The Arctic University of Norway, Tromsø, Norway
-
show less...
-
(creator_code:org_t)
- 2019-04-04
- 2019
- English.
-
In: Plos One. - : Public Library of Science (PLoS). - 1932-6203. ; 14:4
- Related links:
-
https://journals.plo...
-
show more...
-
https://doi.org/10.1...
-
https://his.diva-por... (primary) (Raw object)
-
https://gup.ub.gu.se...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
show less...
Abstract
Subject headings
Close
- Background Hypospadias is the most common congenital anomaly of the penis, but its causes are mainly unknown. Of the risk factors identified, the most plausible are hormonal and genetic. The aim of this study was to identify risk factors for hypospadias in Northwest Russia based on registry data. The study population included male infants registered in the Murmansk County Birth Registry between 1 January 2006 and 31 December 2011 (n = 25 475). These infants were followed-up for 2 years using the Murmansk Regional Congenital Defects Registry to identify cases of hypospadias not diagnosed at birth. We used logistic regression analysis to examine the contributions of hypospadias risk factors. Out of 25 475 male infants born during the study period, 148 had isolated hypospadias. The overall prevalence rate was 54.2 (95% CI 53.6-54.8) per 10 000 male infants. Those born to mothers with preeclampsia (OR = 1.65; 95% CI 1.03-2.66) or infant birthweight < 2500 g (OR = 2.06; 95% CI 1.18-3.60) exhibited increased risk for hypospadias. Maternal age, smoking during pregnancy, folic acid intake during pregnancy or hepatitis B surface antigen positivity did not associate with increased risk of hypospadias. Combining data from a birth registry with those from a congenital defects registry provided optimal information about the prevalence of hypospadias and its association with low infant birthweight and preeclampsia. These factors have in common changes in hormone levels during pregnancy, which in turn may have contributed to hypospadias development.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- malformations
- pregnancy
- exposure
- infants
- sweden
- age
- Science & Technology - Other Topics
- Individual and Society VIDSOC
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
-
Plos One
(Search for host publication in LIBRIS)
To the university's database