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SUPERIOR SVG: no to...
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Deb, S.Sunnybrook Health Sciences Centre, Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada
(author)
SUPERIOR SVG: no touch saphenous harvesting to improve patency following coronary bypass grafting (a multi-Centre randomized control trial, NCT01047449)
- Article/chapterEnglish2019
Publisher, publication year, extent ...
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2019-05-02
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Springer Science and Business Media LLC,2019
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LIBRIS-ID:oai:gup.ub.gu.se/280898
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https://gup.ub.gu.se/publication/280898URI
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https://doi.org/10.1186/s13019-019-0887-xDOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-74197URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Funding Agencies:Heart and Stroke Foundation of Canada 7092 Canadian Institutes of Health Research Centre for Trials Internationally (CANNeCTIN)
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BackgroundSingle centre studies support No Touch (NT) saphenous vein graft (SVG) harvesting technique. The primary objective of the SUPERIOR SVG study was to determine whether NT versus conventional (CON) SVG harvesting was associated with improved SVG patency 1year after coronary artery bypass grafting surgery (CABG).MethodsAdults undergoing isolated CABG with at least 1 SVG were eligible. CT angiography was performed 1-year post CABG. Leg adverse events were assessed with a questionnaire. A systematic review was performed for published NT graft patency studies and results aggregated including the SUPERIOR study results.ResultsTwo hundred and-fifty patients were randomized across 12-centres (NT 127 versus CON 123 patients). The primary outcome (study SVG occlusion or cardiovascular (CV) death) was not significantly different in NT versus CON (NT: 7/127 (5.5%), CON 13/123 (10.6%), p=0.15). Similarly, the proportion of study SVGs with significant stenosis or total occlusion was not significantly different between groups (NT: 8/102 (7.8%), CON: 16/107 (15.0%), p=0.11). Vein harvest site infection was more common in the NT patients 1month postoperatively (23.3% vs 9.5%, p<0.01). Including this study's results, in a meta-analysis, NT was associated with a significant reduction in SVG occlusion, Odds Ratio 0.49, 95% Confidence Interval 0.29-0.82, p=0.007 in 3 randomized and 1 observational study at 1year postoperatively.ConclusionsThe NT technique was not associated with improved patency of SVGs at 1-year following CABG while early vein harvest infection was increased. The aggregated data is supportive of an important reduction of SVG occlusion at 1year with NT harvesting.Trial registrationNCT01047449.
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Singh, S. K.Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
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de Souza, Domingos Ramos,1954-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Cardiothoracic and Vascular Surgery(Swepub:oru)dra
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Chu, M. W. A.Department of Surgery, Western University, London Health Sciences Centre, London, Canada
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Whitlock, R.Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Canada
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Meyer, S. R.Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada
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Verma, S.St. Michael's Hospital, Toronto, Canada
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Jeppsson, Anders,1960Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden(Swepub:gu)xjepan
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Al-Saleh, A.McMaster University, Hamilton, Canada
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Brady, K.Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Canada
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Rao-Melacini, P.Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Canada
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Belley-Cote, E. P.Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Canada
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Tam, D. Y.Sunnybrook Health Sciences Centre, Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada
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Devereaux, P. J.Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Canada
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Novick, R. J.University of Calgary and Foothills Medical Centre, Calgary, Canada
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Fremes, S. E.Sunnybrook Health Sciences Centre, Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada
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Super Svg Study Investigators, Super Svg Study Investigators
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Sunnybrook Health Sciences Centre, Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, CanadaBrigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
(creator_code:org_t)
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In:Journal of Cardiothoracic Surgery: Springer Science and Business Media LLC141749-8090
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Deb, S.
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Singh, S. K.
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de Souza, Doming ...
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Chu, M. W. A.
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Meyer, S. R.
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Verma, S.
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Tam, D. Y.
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Devereaux, P. J.
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Novick, R. J.
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Fremes, S. E.
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Örebro University