Search: onr:"swepub:oai:gup.ub.gu.se/281817" >
Clinical relevance ...
-
Hedna, Khedidja,1978Linköpings universitet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Centrum för åldrande och hälsa (AgeCap),Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Centre for Ageing and Health (Agecap),Institutionen för medicin och hälsa,Medicinska fakulteten,Univ Gothenburg, Sweden
(author)
Clinical relevance of alerts from a decision support system, PHARAO, for drug safety assessment in the older adults
- Article/chapterEnglish2019
Publisher, publication year, extent ...
-
2019-06-11
-
Springer Science and Business Media LLC,2019
Numbers
-
LIBRIS-ID:oai:gup.ub.gu.se/281817
-
https://gup.ub.gu.se/publication/281817URI
-
https://doi.org/10.1186/s12877-019-1179-yDOI
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:141146680URI
-
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-158875URI
Supplementary language notes
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Funding Agencies|National Corporation of Swedish Pharmacies (Apoteket AB); Linkoping university; Region Ostergotland; Region Vastra Gotaland
-
BackgroundPHARAO is a decision support system developed to evaluate the risk for a set of either common or serious side-effects resulting from a combination of pharmacodynamic effects from a patient's medications. The objective of this study was to investigate the validity of the risk scores for the common side-effects generated by PHARAO in older patients.MethodsSide-effects included were sedation, constipation, orthostatic symptoms, anticholinergic and serotonergic effects. The alerts generated by PHARAO were tested in 745 persons 65years old. Dispensed prescriptions retrieved from the Swedish prescribed drug register were used to generate the pharmacological risk scores of patients' medications. Symptoms possibly related to side-effects were extracted from medical records data.ResultsThe PHARAO system generated 776 alerts, most often for the risk of anticholinergic symptoms. The total specificity estimates of the PHARAO system were 0.95, 0.89 and 0.78 for high, intermediate and low risk alerts, respectively. The corresponding sensitivity estimates were between 0.12 and 0.37. The negative predictive value was 0.90 and the positive predictive value ranged between 0.20-0.25.ConclusionsThe PHARAO system had a high specificity and negative predictive value to detect symptoms possibly associated with the of patients' medications, while the sensitivity and positive predictive value were low. The PHARAO system has the potential to minimise the risk of over-alerts in combination with a drug-drug interaction alert system, but should be used in connection with a medical evaluation of the patient.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Andersson, M. L.Karolinska Institutet,Karolinska Inst, Sweden
(author)
-
Gyllensten, Hanna,1979Karolinska Institutet,Gothenburg University,Göteborgs universitet,Centrum för personcentrerad vård vid Göteborgs universitet (GPCC),Extern,Institutionen för vårdvetenskap och hälsa,University of Gothenburg Centre for person-centred care (GPCC),External,Institute of Health and Care Sciences,Karolinska Inst, Sweden; Univ Gothenburg, Sweden; Univ Gothenburg, Sweden(Swepub:gu)xgylha
(author)
-
Hägg, Staffan,1963-Linköpings universitet,Avdelningen för läkemedelsforskning,Medicinska fakulteten,Region Östergötland, Klinisk farmakologi,Futurum, Sweden(Swepub:liu)staha06
(author)
-
Böttiger, YlvaLinköpings universitet,Avdelningen för läkemedelsforskning,Medicinska fakulteten,Region Östergötland, Klinisk farmakologi(Swepub:liu)ylvbo14
(author)
-
Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi
(creator_code:org_t)
Related titles
-
In:BMC Geriatrics: Springer Science and Business Media LLC19:1, s. 164-1471-2318
Internet link
Find in a library
To the university's database