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A 16-yr Follow-up o...
A 16-yr Follow-up of the European Randomized study of Screening for Prostate Cancer
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- Hugosson, Jonas, 1955 (author)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för socialt arbete,Institutionen för kliniska vetenskaper, Avdelningen för urologi,Department of Social Work,Institute of Clinical Sciences, Department of Urology
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- Månsson, Marianne, 1964 (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Institutionen för kliniska vetenskaper, Avdelningen för urologi,Institute of Clinical Sciences, Department of Urology
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- Månsson, Marianne, 1964 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för urologi,Institute of Clinical Sciences, Department of Urology,Finnish Cancer Registry,Queen Mary University
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- Tammela, T. L. J. (author)
- University of Tampere
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- Zappa, M. (author)
- Cancer Research and Prevention Institute (ISPO)
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- Nelen, V. (author)
- Provinciaal Instituut voor Hygiëne
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- Kwiatkowski, M. (author)
- Städtische Klinikum Braunschweig,Cantonal Hospital Aarau
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- Lujan, M. (author)
- Infanta Cristina University Hospital
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- Carlsson, Sigrid, 1982 (author)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för urologi,Institute of Clinical Sciences, Department of Urology,Memorial Sloan-Kettering Cancer Center
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Talala, K. M. (author)
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- Lilja, Hans (author)
- Lund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups,University of Oxford,Memorial Sloan-Kettering Cancer Center
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- Denis, L. J. (author)
- Oncology Centre of Antwerp
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- Recker, F. (author)
- Cantonal Hospital Aarau
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- Paez, A. (author)
- Fuenlabrada University Hospital
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- Puliti, D. (author)
- Cancer Research and Prevention Institute (ISPO)
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- Villers, A. (author)
- Lille University Hospital,University of Lille
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- Rebillard, X. (author)
- Clinique Beau Soleil
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- Kilpelainen, T. P. (author)
- Helsinki University Central Hospital,University of Helsinki
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- Stenman, U. H. (author)
- Fimlab Laboratories
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- Godtman, Rebecka Arnsrud, 1981 (author)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för urologi,Institute of Clinical Sciences, Department of Urology
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- Stinesen-Kollberg, Karin (author)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för urologi,Institute of Clinical Sciences, Department of Urology
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Moss, S. M. (author)
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- Kujala, P. (author)
- Fimlab Laboratories
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- Taari, K. (author)
- Helsinki University Central Hospital,University of Helsinki
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- Huber, A. (author)
- Cantonal Hospital Aarau
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- van der Kwast, T. (author)
- University Health Network University of Toronto
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- Heijnsdijk, E. A. (author)
- Erasmus University Medical Center,University of Tampere
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- Bangma, C. (author)
- Erasmus University Medical Center
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- De Koning, H. J. (author)
- Erasmus University Medical Center
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- Schroder, F. H. (author)
- Erasmus University Medical Center
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Auvinen, A. (author)
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(creator_code:org_t)
- Elsevier BV, 2019
- 2019
- English.
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In: European Urology. - : Elsevier BV. - 0302-2838. ; 76:1, s. 43-51
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Abstract
Subject headings
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- Background: The European Randomized study of Screening for Prostate Cancer (ERSPC) has previously demonstrated that prostate-specific antigen (PSA) screening decreases prostate cancer (PCa) mortality. Objective: To determine whether PSA screening decreases PCa mortality for up to 16 yr and to assess results following adjustment for nonparticipation and the number of screening rounds attended. Design, setting, and participants: This multicentre population-based randomised screening trial was conducted in eight European countries. Report includes 182 160 men, followed up until 2014 (maximum of 16 yr), with a predefined core age group of 162 389 men (55-69 yr), selected from population registry. Outcome measurements and statistical analysis: The outcome was PCa mortality, also assessed with adjustment for nonparticipation and the number of screening rounds attended. Results and limitations: The rate ratio of PCa mortality was 0.80 (95% confidence interval [CI] 0.72-0.89, p < 0.001) at 16 yr. The difference in absolute PCa mortality increased from 0.14% at 13 yr to 0.18% at 16 yr. The number of men needed to be invited for screening to prevent one PCa death was 570 at 16 yr compared with 742 at 13 yr. The number needed to diagnose was reduced to 18 from 26 at 13 yr. Men with PCa detected during the first round had a higher prevalence of PSA >20 ng/ml (9.9% compared with 4.1% in the second round, p < 0.001) and higher PCa mortality (hazard ratio = 1.86, p < 0.001) than those detected subsequently. Conclusions: Findings corroborate earlier results that PSA screening significantly reduces PCa mortality, showing larger absolute benefit with longer follow-up and a reduction in excess incidence. Repeated screening may be important to reduce PCa mortality on a population level. Patient summary: In this report, we looked at the outcomes from prostate cancer in a large European population. We found that repeated screening reduces the risk of dying from prostate cancer. (C) 2019 Published by Elsevier B.V. on behalf of European Association of Urology.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- Prostate cancer
- Screening
- Prostate-specific antigen
- Mortality
- mortality
- erspc
- death
- risk
- Urology & Nephrology
- mets dl
- 1994
- statistics in medicine
- v13
- p1341
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Hugosson, Jonas, ...
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Månsson, Mariann ...
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Tammela, T. L. J ...
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Zappa, M.
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Nelen, V.
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Kwiatkowski, M.
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Lujan, M.
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Carlsson, Sigrid ...
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Talala, K. M.
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Lilja, Hans
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Denis, L. J.
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Recker, F.
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Paez, A.
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Puliti, D.
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Villers, A.
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Rebillard, X.
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Kilpelainen, T. ...
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Stenman, U. H.
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Godtman, Rebecka ...
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Stinesen-Kollber ...
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Moss, S. M.
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Kujala, P.
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Taari, K.
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Huber, A.
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van der Kwast, T ...
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Heijnsdijk, E. A ...
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Bangma, C.
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De Koning, H. J.
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Schroder, F. H.
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Auvinen, A.
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- Articles in the publication
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European Urology
- By the university
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University of Gothenburg
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Lund University