SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:gup.ub.gu.se/281855"
 

Search: onr:"swepub:oai:gup.ub.gu.se/281855" > Current clinical pr...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Na, I. K. (author)

Current clinical practice and challenges in the management of secondary immunodeficiency in hematological malignancies

  • Article/chapterEnglish2019

Publisher, publication year, extent ...

  • 2019-03-24
  • Wiley,2019

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/281855
  • https://gup.ub.gu.se/publication/281855URI
  • https://doi.org/10.1111/ejh.13223DOI

Supplementary language notes

  • Language:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Objective Despite long-standing safe and effective use of immunoglobulin replacement therapy (IgRT) in primary immunodeficiency, clinical data on IgRT in patients with secondary immunodeficiency (SID) due to B-cell lymphoproliferative diseases are limited. Here, we examine the correlation between approved IgRT indications, treatment recommendations, and clinical practice in SID. Methods An international online survey of 230 physicians responsible for the diagnosis of SID and the prescription of IgRT in patients with hematological malignancies was conducted. Results Serum immunoglobulin was measured in 83% of patients with multiple myeloma, 76% with chronic lymphocytic leukemia, and 69% with non-Hodgkin lymphoma. Most physicians (85%) prescribed IgRT after >= 2 severe infections. In Italy, Germany, Spain, and the United States, immunoglobulin use was above average in patients with hypogammaglobulinemia, while in the UK considerably fewer patients received IgRT. The use of subcutaneous immunoglobulin was highest in France (34%) and lowest in Spain (19%). Immunologists measured specific antibody responses, performed test immunization, implemented IgRT, and used subcutaneous immunoglobulin more frequently than physicians overall. Conclusions The management of SID in hematological malignancies varied regionally. Clinical practice did not reflect treatment guidelines, highlighting the need for robust clinical studies on IgRT in this population and harmonization between countries and disciplines.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Buckland, M. (author)
  • Agostini, C. (author)
  • Edgar, J. D. M. (author)
  • Friman, Vanda,1952Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine(Swepub:gu)xfriva (author)
  • Michallet, M. (author)
  • Sanchez-Ramon, S. (author)
  • Scheibenbogen, C. (author)
  • Quinti, I. (author)
  • Göteborgs universitetInstitutionen för biomedicin, avdelningen för infektionssjukdomar (creator_code:org_t)

Related titles

  • In:European Journal of Haematology: Wiley102:6, s. 447-4560902-44411600-0609

Internet link

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view