Splanchnic Circulation and Intraabdominal Metabolism in Two Porcine Models of Low Cardiac Output

• The impact of acute cardiac dysfunction on the gastrointestinal tract was investigated in anesthetized and instrumented pigs by sequential reductions of cardiac output (CO). Using a cardiac tamponade (n=6) or partial inferior caval vein balloon inflation (n=6), CO was controllably reduced for 1h each to 75% (CO75%), 50% (CO50%), and 35% (CO35%) of the baseline value. Cardiac output in controls (n=6) was not manipulated and maintained. Mean arterial pressure, superior mesenteric arterial blood flow, and intestinal mucosal perfusion started to decrease at CO50% in the intervention groups. The decrease in superior mesenteric arterial blood flow was non-linear and exaggerated at CO35%. Systemic, venous mesenteric, and intraperitoneal lactate concentrations increased in the intervention groups from CO50%. Global and mesenteric oxygen uptake decreased at CO35%. In conclusion, gastrointestinal metabolism became increasingly anaerobic when CO was reduced by 50%. Anaerobic gastrointestinal metabolism in low CO can be detected using intraperitoneal microdialysis.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

Keyword

Cardiac dysfunction

Cardiac tamponade

Caval vein balloon

Porcine model

Intraperitoneal microdialysis

Laser Doppler flowmetry

blood-flow

intraperitoneal microdialysis

oxygen-consumption

gastrointestinal complications

cardiopulmonary bypass

mesenteric

ischemia

tamponade

levosimendan

dysfunction

reduction

Cardiovascular System & Cardiology

Research & Experimental Medicine

ichman gc

1984

canadian journal of physiology and pharmacology

v62

p539

backer d

1995

shock

v4

p107

Cardiac dysfunction

Publication and Content Type

ref (subject category)

art (subject category)