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Bone Immune Respons...
Bone Immune Response to Materials, Part II:Copper and Polyetheretherketone (PEEK) Compared to Titanium at 10 and 28 Days in Rabbit Tibia
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- Trindade, Ricardo (author)
- Gothenburg University,Göteborgs universitet,Institutionen för odontologi,Institute of Odontology,Department of Prosthodontics, Institute of Odontology, The Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden
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- Albrektsson, Tomas, 1945 (author)
- Malmö universitet,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institute of Clinical Sciences, Department of Biomaterials,Odontologiska fakulteten (OD),Biofilms Research Center for Biointerfaces
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- Galli, Silvia (author)
- Malmö universitet,Odontologiska fakulteten (OD),Biofilms Research Center for Biointerfaces
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- Prgomet, Zdenka (author)
- Malmö universitet,Odontologiska fakulteten (OD),Biofilms Research Center for Biointerfaces
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- Tengvall, Pentti (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institute of Clinical Sciences, Department of Biomaterials
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- Wennerberg, Ann, 1955 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för odontologi,Institute of Odontology,Department of Prosthodontics, Institute of Odontology, The Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden
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(creator_code:org_t)
- 2019-06-07
- 2019
- English.
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In: Journal of Clinical Medicine. - : MDPI AG. - 2077-0383. ; 8:6
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https://doi.org/10.3...
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Abstract
Subject headings
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- Osseointegration is likely the result of an immunologically driven bone reaction to materials such as titanium. Osseointegration has resulted in the clinical possibility to anchor oral implants in jaw bone tissue. However, the mechanisms behind bony anchorage are not fully understood and complications over a longer period of time have been reported. The current study aims at exploring possible differences between copper (Cu) and polyetheretherketone (PEEK) materials that do not osseointegrate, with osseointegrating cp titanium as control. The implants were placed in rabbit tibia and selected immune markers were evaluated at 10 and 28 days of follow-up. Cu and PEEK demonstrated at both time points a higher immune activation than cp titanium. Cu demonstrated distance osteogenesis due to a maintained proinflammatory environment over time, and PEEK failed to osseointegrate due to an immunologically defined preferential adipose tissue formation on its surface. The here presented results suggest the description of two different mechanisms for failed osseointegration, both of which are correlated to the immune system.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
Keyword
- biomaterial
- bone
- osseointegration
- immune
- implant
- healing
- titanium
- PEEK
- Cu
- foreign-body reaction
- oral implants
- cells
- osseointegration
- particles
- marrow
- General & Internal Medicine
- biomaterial
Publication and Content Type
- ref (subject category)
- art (subject category)
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