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Requirement for YAP...
Requirement for YAP1 signaling in myxoid liposarcoma.
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Trautmann, Marcel (author)
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Cheng, Ya-Yun (author)
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Jensen, Patrizia (author)
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Azoitei, Ninel (author)
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Brunner, Ines (author)
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Hüllein, Jennifer (author)
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Slabicki, Mikolaj (author)
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Isfort, Ilka (author)
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Cyra, Magdalene (author)
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Berthold, Ruth (author)
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Wardelmann, Eva (author)
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Huss, Sebastian (author)
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Altvater, Bianca (author)
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Rossig, Claudia (author)
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Hafner, Susanne (author)
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Simmet, Thomas (author)
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- Ståhlberg, Anders, 1975 (author)
- Gothenburg University,Göteborgs universitet,Wallenberg Centre for Molecular and Translational Medicine,Sahlgrenska Cancer Center,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine
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- Åman, Pierre, 1953 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Sahlgrenska Cancer Center,Department of Laboratory Medicine
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Zenz, Thorsten (author)
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Lange, Undine (author)
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Kindler, Thomas (author)
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Scholl, Claudia (author)
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Hartmann, Wolfgang (author)
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Fröhling, Stefan (author)
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(creator_code:org_t)
- 2019-03-21
- 2019
- English.
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In: EMBO molecular medicine. - : EMBO. - 1757-4684 .- 1757-4676. ; 11:5
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https://doi.org/10.1...
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Abstract
Subject headings
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- Myxoid liposarcomas (MLS), malignant tumors of adipocyte origin, are driven by the FUS-DDIT3 fusion gene encoding an aberrant transcription factor. The mechanisms whereby FUS-DDIT3 mediates sarcomagenesis are incompletely understood, and strategies to selectively target MLS cells remain elusive. Here we show, using an unbiased functional genomic approach, that FUS-DDIT3-expressing mesenchymal stem cells and MLS cell lines are dependent on YAP1, a transcriptional co-activator and central effector of the Hippo pathway involved in tissue growth and tumorigenesis, and that increased YAP1 activity is a hallmark of human MLS Mechanistically, FUS-DDIT3 promotes YAP1 expression, nuclear localization, and transcriptional activity and physically associates with YAP1 in the nucleus of MLS cells. Pharmacologic inhibition of YAP1 activity impairs the growth of MLS cells invitro and invivo These findings identify overactive YAP1 signaling as unifying feature of MLS development that could represent a novel target for therapeutic intervention.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- FUS‐DDIT3
- Hippo pathway
- YAP1; myxoid liposarcoma
- verteporfin
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Trautmann, Marce ...
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Cheng, Ya-Yun
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Jensen, Patrizia
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Azoitei, Ninel
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Brunner, Ines
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Hüllein, Jennife ...
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show more...
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Slabicki, Mikola ...
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Isfort, Ilka
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Cyra, Magdalene
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Berthold, Ruth
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Wardelmann, Eva
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Huss, Sebastian
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Altvater, Bianca
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Rossig, Claudia
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Hafner, Susanne
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Simmet, Thomas
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Ståhlberg, Ander ...
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Åman, Pierre, 19 ...
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Zenz, Thorsten
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Lange, Undine
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Kindler, Thomas
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Scholl, Claudia
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Hartmann, Wolfga ...
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Fröhling, Stefan
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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EMBO molecular m ...
- By the university
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University of Gothenburg