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A sensitive method ...
A sensitive method detecting trace levels of levonorgestrel using LC-HRMS
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- Abujrais, Sandy (author)
- Uppsala universitet,Klinisk kemi
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- Olovsson, Matts, 1958- (author)
- Uppsala universitet,Reproduktionsbiologi
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- Ahnoff, Martin (author)
- Gothenburg University,Göteborgs universitet,Institutionen för marina vetenskaper,Department of marine sciences,Department of Marine Sciences, University of Gothenburg, Carl Skottbergs gata 22B, SE-41319 Gothenburg, Sweden.
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- Rasmusson, Annica (author)
- Uppsala universitet,Klinisk farmakogenomik och osteoporos
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- Larsson, Anders (author)
- Uppsala universitet,Klinisk kemi
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- Åkerfeldt, Torbjörn (author)
- Uppsala universitet,Klinisk kemi
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- Kultima, Kim (author)
- Uppsala universitet,Klinisk kemi
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(creator_code:org_t)
- Elsevier BV, 2019
- 2019
- English.
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In: Contraception. - : Elsevier BV. - 0010-7824 .- 1879-0518. ; 100:3, s. 247-249
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https://doi.org/10.1...
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Abstract
Subject headings
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- Objective: To develop a high resolution mass spectrometry (HRMS) method to quantify levonorgestrel (LNG) in serum. Study design: Levonorgestrel was extracted using solid phase extraction and measured using liquid chromatography (LC) HRMS. Results: Low limit of quantification (LLOQ) was 25 pg/mL and low limit of detection (LLOD) was 12.5 pg/mL. Precision and accuracy bias were <10%. LNG in serum samples from Mirena® users ranged between 37 to 219 pg/mL (n=12). In eight out of 22 patients with suspected intrauterine device (IUD) expulsion LNG was detected (26–1272 pg/mL). Conclusion: A sensitive, fast and simple LC-HRMS method was developed to detect trace levels of LNG. © 2019 Elsevier Inc.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Keyword
- High resolution mass spectrometry
- Intrauterine device
- Liquid chromatography
- Lower limit of quantification
- Solid phase extraction
- High resolution mass spectrometry
Publication and Content Type
- ref (subject category)
- art (subject category)
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