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Correlation between...
Correlation between plasma and CSF concentrations of kynurenine pathway metabolites in Alzheimer's disease and relationship to amyloid-beta and tau
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Jacobs, K. R. (author)
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Lim, C. K. (author)
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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Chatterjee, P. (author)
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Martins, R. N. (author)
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Brew, B. J. (author)
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Guillemin, G. J. (author)
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Lovejoy, D. B. (author)
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(creator_code:org_t)
- Elsevier BV, 2019
- 2019
- English.
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In: Neurobiology of Aging. - : Elsevier BV. - 0197-4580. ; 80, s. 11-20
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Abstract
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- Chronic kynurenine pathway (KP) activation is implicated in Alzheimer's disease (AD) pathophysiology and results in quinolinic acid-induced excitotoxic stimulation of the N-methyl-D-aspartate receptor. However, most studies focus on plasma and it is unclear if peripheral concentrations reflect brain concentrations and how these may correlate to the AD biomarkers amyloid-beta, total-tau (t-tau), or phosphorylated-tau (p-tau). We characterized the KP in matched plasma and cerebrospinal fluid (CSF) samples from 20 AD patients and 18 age-matched control subjects. Plasma concentrations of kynurenine (KYN), 3-hydroxykynurenine, anthranilic acid, picolinic acid, and neopterin significantly correlated with their respective CSF levels. In patients with AD, plasma KYN (r = -0.48, p = 0.033) and picolinic acid (r = -0.57, p = 0.009) inversely correlated with CSF p-tau and t-tau, respectively. Furthermore, in AD CSF, increased 3-hydroxykynurenine/KYN ratio correlated with t-tau (r = 0.58, p = 0.009) and p-tau (r = 0.52, p = 0.020). These data support KP involvement in AD pathogenesis and add to the case for the therapeutic modulation of the KP in AD. (C) 2019 Published by Elsevier Inc.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Alzheimer's disease
- Kynurenine pathway
- Amyloid-beta
- Tau protein
- Cerebrospinal fluid
- Disease
- cerebrospinal-fluid
- 3-hydroxyanthranilic acid
- indoleamine
- 2
- 3-dioxygenase
- quinolinate levels
- hydrogen-peroxide
- human microglia
- brain
- 3-hydroxykynurenine
- tryptophan
- astrocytes
- Geriatrics & Gerontology
- Neurosciences & Neurology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Jacobs, K. R.
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Lim, C. K.
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Blennow, Kaj, 19 ...
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Zetterberg, Henr ...
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Chatterjee, P.
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Martins, R. N.
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show more...
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Brew, B. J.
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Guillemin, G. J.
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Lovejoy, D. B.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Neurobiology of ...
- By the university
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University of Gothenburg