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Outflanking immunodominance to target subdominant broadly neutralizing epitopes
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- Angeletti, Davide, 1984 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology
- Kosik, I. (author)
- Santos, J. J. S. (author)
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- Yewdell, W. T. (author)
- Boudreau, C. M. (author)
- Mallajosyula, V. V. A. (author)
- Mankowski, M. C. (author)
- Chambers, M. (author)
- Prabhakaran, M. (author)
- Hickman, H. D. (author)
- McDermott, A. B. (author)
- Alter, G. (author)
- Chaudhuri, J. (author)
- Yewdell, J. W. (author)
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- (creator_code:org_t)
- 2019-06-18
- 2019
- English.
- In: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424. ; 116:27, s. 13474-13479
- Journal article (peer-reviewed)
Abstract
Subject headings
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- A major obstacle to vaccination against antigenically variable viruses is skewing of antibody responses to variable immunodominant epitopes. For influenza virus hemagglutinin (HA), the immunodominance of the variable head impairs responses to the highly conserved stem. Here, we show that head immunodominance depends on the physical attachment of head to stem. Stem immunogenicity is enhanced by immunizing with stem-only constructs or by increasing local HA concentration in the draining lymph node. Surprisingly, coimmunization of full-length HA and stem alters stem-antibody class switching. Our findings delineate strategies for overcoming immunodominance, with important implications for human vaccination. © 2019 National Academy of Sciences. All rights reserved.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- Antibodies
- B cell
- Hemagglutinin
- Immunodominance
- Influenza
Publication and Content Type
- ref (subject category)
- art (subject category)
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- Kosik, I.
- Santos, J. J. S.
- Yewdell, W. T.
- Boudreau, C. M.
- Mallajosyula, V. ...
- show more...
- Mankowski, M. C.
- Chambers, M.
- Prabhakaran, M.
- Hickman, H. D.
- McDermott, A. B.
- Alter, G.
- Chaudhuri, J.
- Yewdell, J. W.
- show less...
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