Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa

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Watson, H. J. (author)

Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa

Article/chapterEnglish2019

Publisher, publication year, extent ...

2019-07-15
Springer Science and Business Media LLC,2019

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LIBRIS-ID:oai:gup.ub.gu.se/282982
https://gup.ub.gu.se/publication/282982URI
https://doi.org/10.1038/s41588-019-0439-2DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:141444927URI

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Language:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Characterized primarily by a low body-mass index, anorexia nervosa is a complex and serious illness(1), affecting 0.9-4% of women and 0.3% of men(2-4), with twin-based heritability estimates of 50-60%(5). Mortality rates are higher than those in other psychiatric disorders(6), and outcomes are unacceptably poor(7). Here we combine data from the Anorexia Nervosa Genetics Initiative (ANGI)(8,9) and the Eating Disorders Working Group of the Psychiatric Genomics Consortium (PGC-ED) and conduct a genome-wide association study of 16,992 cases of anorexia nervosa and 55,525 controls, identifying eight significant loci. The genetic architecture of anorexia nervosa mirrors its clinical presentation, showing significant genetic correlations with psychiatric disorders, physical activity, and metabolic (including glycemic), lipid and anthropometric traits, independent of the effects of common variants associated with body-mass index. These results further encourage a reconceptualization of anorexia nervosa as a metabo-psychiatric disorder. Elucidating the metabolic component is a critical direction for future research, and paying attention to both psychiatric and metabolic components may be key to improving outcomes.

Subject headings and genre

NATURVETENSKAP Biologi Genetik hsv//swe
NATURAL SCIENCES Biological Sciences Genetics hsv//eng
ld score regression
eating-disorders
genetic correlations
polygenic
risk
comorbidity
prevalence
heritability
variants
insights
myc
Genetics & Heredity

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Yilmaz, Z. (author)
Thorntont, L. M.Karolinska Institutet (author)
Hubel, C.Karolinska Institutet (author)
Coleman, J. R. I. (author)
Gaspar, H. A. (author)
Bryois, J.Karolinska Institutet (author)
Adan, Roger A. H.Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology(Swepub:gu)xadaro (author)
Leppa, V. M.Karolinska Institutet (author)
Mattheisen, M.Karolinska Institutet (author)
Medland, S. E. (author)
Ripke, S. (author)
Yao, S. Y.Karolinska Institutet (author)
Giusti-Rodriguez, P. (author)
Hanscombe, K. B. (author)
Purves, K. L.Karolinska Institutet (author)
Adan, Roger A. H.Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology(Swepub:gu)xadaro (author)
Alfredsson, L.Karolinska Institutet (author)
Ando, T. (author)
Andreassen, O. A. (author)
Baker, J. H. (author)
Berrettini, W. H. (author)
Boehm, I. (author)
Boni, C. (author)
Perica, V. B. (author)
Buehren, K. (author)
Burghardt, R. (author)
Cassina, M. (author)
Cichon, S. (author)
Clementi, M. (author)
Cone, R. D. (author)
Courtet, P. (author)
Crow, S. (author)
Crowley, J. J. (author)
Danner, U. N. (author)
Davis, O. S. P. (author)
de Zwaan, M. (author)
Dedoussis, G. (author)
Degortes, D. (author)
DeSocio, J. E. (author)
Dick, D. M. (author)
Dikeos, D. (author)
Dina, C. (author)
Dmitrzak-Weglarz, M. (author)
Docampo, E. (author)
Duncan, L. E. (author)
Egberts, K. (author)
Ehrlich, S. (author)
Escaramis, G. (author)
Eskos, T. (author)
Estivill, X. (author)
Farmer, A. (author)
Favaro, A. (author)
Fernandez-Aranda, F. (author)
Fichter, M. M. (author)
Fischer, K. (author)
Focker, M. (author)
Foretova, L. (author)
Forstner, A. J. (author)
Forzan, M. (author)
Franklin, C. S. (author)
Gallinger, S. (author)
Giegling, I. (author)
Giuranna, J. (author)
Gonidakis, F. (author)
Gorwood, P. (author)
Mayora, M. G. (author)
Guillaume, S. (author)
Guo, Y. R. (author)
Hakonarson, H. (author)
Hatzikotoulas, K. (author)
Hauser, J. (author)
Hebebrand, J. (author)
Helder, S. G. (author)
Herms, S. (author)
Herpertz-Dahlmann, B. (author)
Herzog, W. (author)
Huckins, L. M. (author)
Hudson, J. I. (author)
Imgart, H. (author)
Inoko, H. (author)
Janout, V. (author)
Jimenez-Murcia, S. (author)
Julia, A. (author)
Kalsi, G. (author)
Kaminska, D. (author)
Kaprio, J. (author)
Karhunen, L. (author)
Karwautz, A. (author)
Kas, M. J. H. (author)
Kennedy, J. L. (author)
Keski-Rahkonen, A. (author)
Kiezebrink, K. (author)
Kim, Y. R. (author)
Klareskog, L. (author)
Klump, K. L. (author)
Knudsen, G. P. S. (author)
La Via, M. C. (author)
Le Hellard, S. (author)
Levitan, R. D. (author)
Li, D. (author)
Lilenfeld, L.Karolinska Institutet (author)
Lin, B. D. (author)
Lissowska, J. (author)
Luykx, J. (author)
Magistretti, P. J. (author)
Maj, M. (author)
Mannik, K. (author)
Marsal, S. (author)
Marshall, C. R. (author)
Mattingsdal, M. (author)
McDevitt, S. (author)
McGuffin, P. (author)
Metspalu, A. (author)
Meulenbelt, I. (author)
Micali, N. (author)
Mitchell, K. (author)
Monteleone, A. M. (author)
Monteleone, P. (author)
Munn-Chernoff, M. A. (author)
Nacmias, B. (author)
Navratilova, M. (author)
Ntalla, I. (author)
O'Toole, J. K. (author)
Ophoff, R. A. (author)
Padyukov, L. (author)
Palotie, A. (author)
Pantel, J. (author)
Papezova, H. (author)
Pinto, D. (author)
Rabionet, R. (author)
Raevuori, A. (author)
Ramoz, N. (author)
Reichborn-Kjennerud, T. (author)
Ricca, V. (author)
Ripatti, S. (author)
Ritschel, F. (author)
Roberts, M. (author)
Rotondo, A. (author)
Rujescu, D. (author)
Rybakowski, F. (author)
Santonastaso, P. (author)
Scherag, A. (author)
Scherer, S. W. (author)
Schmidt, U. (author)
Schork, N. J. (author)
Schosser, A. (author)
Seitz, J. (author)
Slachtova, L. (author)
Slagboom, P. E. (author)
t Landt, Mctso (author)
Slopien, A. (author)
Sorbi, S. (author)
Swiatkowska, B. (author)
Szatkiewicz, J. P. (author)
Tachmazidou, I. (author)
Tenconi, E. (author)
Tortorella, A. (author)
Tozzi, F. (author)
Treasure, J. (author)
Tsitsika, A. (author)
Tyszkiewicz-Nwafor, M. (author)
Tziouvas, K. (author)
van Elbur, A. A. (author)
van Furth, E. F. (author)
Wagner, G. (author)
Walton, E. (author)
Widen, E. (author)
Zeggini, E. (author)
Zerwas, S. (author)
Zipfel, S. (author)
Bergen, A. W. (author)
Boden, J. M. (author)
Brandt, H. (author)
Crawford, S. (author)
Halmi, K. A. (author)
Horwood, L. J. (author)
Johnson, C. (author)
Kaplan, A. S. (author)
Kaye, W. H. (author)
Mitchell, J. E. (author)
Olsen, C. M. (author)
Pearson, J. F. (author)
Pedersen, N. L. (author)
Strober, M. (author)
Werge, T. (author)
Whiteman, D. C. (author)
Woodside, D. B. (author)
Stuber, G. D. (author)
Gordon, S. (author)
Grove, J. (author)
Henders, A. K. (author)
Jureus, A. (author)
Kirk, K. M. (author)
Larsen, J. T. (author)
Parker, R. (author)
Petersen, L. (author)
Jordan, J. (author)
Kennedy, M. (author)
Montgomery, G. W. (author)
Wade, T. D. (author)
Birgegard, A.Karolinska Institutet (author)
Lichtenstein, P. (author)
Norring, C.Karolinska Institutet (author)
Landen, M. (author)
Martin, N. G. (author)
Mortensen, P. B. (author)
Sullivan, P. F.Karolinska Institutet (author)
Breen, G. (author)
Bulik, C. M. (author)
Karolinska InstitutetInstitutionen för neurovetenskap och fysiologi, sektionen för fysiologi (creator_code:org_t)

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By the author/editor: Watson, H. J.; Yilmaz, Z.; Thorntont, L. M.; Hubel, C.; Coleman, J. R. I ...; Gaspar, H. A.; show more...; Bryois, J.; Adan, Roger A. H ...; Leppa, V. M.; Mattheisen, M.; Medland, S. E.; Ripke, S.; Yao, S. Y.; Giusti-Rodriguez ...; Hanscombe, K. B.; Purves, K. L.; Alfredsson, L.; Ando, T.; Andreassen, O. A ...; Baker, J. H.; Berrettini, W. H ...; Boehm, I.; Boni, C.; Perica, V. B.; Buehren, K.; Burghardt, R.; Cassina, M.; Cichon, S.; Clementi, M.; Cone, R. D.; Courtet, P.; Crow, S.; Crowley, J. J.; Danner, U. N.; Davis, O. S. P.; de Zwaan, M.; Dedoussis, G.; Degortes, D.; DeSocio, J. E.; Dick, D. M.; Dikeos, D.; Dina, C.; Dmitrzak-Weglarz ...; Docampo, E.; Duncan, L. E.; Egberts, K.; Ehrlich, S.; Escaramis, G.; Eskos, T.; Estivill, X.; Farmer, A.; Favaro, A.; Fernandez-Aranda ...; Fichter, M. M.; Fischer, K.; Focker, M.; Foretova, L.; Forstner, A. J.; Forzan, M.; Franklin, C. S.; Gallinger, S.; Giegling, I.; Giuranna, J.; Gonidakis, F.; Gorwood, P.; Mayora, M. G.; Guillaume, S.; Guo, Y. R.; Hakonarson, H.; Hatzikotoulas, K ...; Hauser, J.; Hebebrand, J.; Helder, S. G.; Herms, S.; Herpertz-Dahlman ...; Herzog, W.; Huckins, L. M.; Hudson, J. I.; Imgart, H.; Inoko, H.; Janout, V.; Jimenez-Murcia, ...; Julia, A.; Kalsi, G.; Kaminska, D.; Kaprio, J.; Karhunen, L.; Karwautz, A.; Kas, M. J. H.; Kennedy, J. L.; Keski-Rahkonen, ...; Kiezebrink, K.; Kim, Y. R.; Klareskog, L.; Klump, K. L.; Knudsen, G. P. S ...; La Via, M. C.; Le Hellard, S.; Levitan, R. D.; Li, D.; Lilenfeld, L.; Lin, B. D.; Lissowska, J.; Luykx, J.; Magistretti, P. ...; Maj, M.; Mannik, K.; Marsal, S.; Marshall, C. R.; Mattingsdal, M.; McDevitt, S.; McGuffin, P.; Metspalu, A.; Meulenbelt, I.; Micali, N.; Mitchell, K.; Monteleone, A. M ...; Monteleone, P.; Munn-Chernoff, M ...; Nacmias, B.; Navratilova, M.; Ntalla, I.; O'Toole, J. K.; Ophoff, R. A.; Padyukov, L.; Palotie, A.; Pantel, J.; Papezova, H.; Pinto, D.; Rabionet, R.; Raevuori, A.; Ramoz, N.; Reichborn-Kjenne ...; Ricca, V.; Ripatti, S.; Ritschel, F.; Roberts, M.; Rotondo, A.; Rujescu, D.; Rybakowski, F.; Santonastaso, P.; Scherag, A.; Scherer, S. W.; Schmidt, U.; Schork, N. J.; Schosser, A.; Seitz, J.; Slachtova, L.; Slagboom, P. E.; t Landt, Mctso; Slopien, A.; Sorbi, S.; Swiatkowska, B.; Szatkiewicz, J. ...; Tachmazidou, I.; Tenconi, E.; Tortorella, A.; Tozzi, F.; Treasure, J.; Tsitsika, A.; Tyszkiewicz-Nwaf ...; Tziouvas, K.; van Elbur, A. A.; van Furth, E. F.; Wagner, G.; Walton, E.; Widen, E.; Zeggini, E.; Zerwas, S.; Zipfel, S.; Bergen, A. W.; Boden, J. M.; Brandt, H.; Crawford, S.; Halmi, K. A.; Horwood, L. J.; Johnson, C.; Kaplan, A. S.; Kaye, W. H.; Mitchell, J. E.; Olsen, C. M.; Pearson, J. F.; Pedersen, N. L.; Strober, M.; Werge, T.; Whiteman, D. C.; Woodside, D. B.; Stuber, G. D.; Gordon, S.; Grove, J.; Henders, A. K.; Jureus, A.; Kirk, K. M.; Larsen, J. T.; Parker, R.; Petersen, L.; Jordan, J.; Kennedy, M.; Montgomery, G. W ...; Wade, T. D.; Birgegard, A.; Lichtenstein, P.; Norring, C.; Landen, M.; Martin, N. G.; Mortensen, P. B.; Sullivan, P. F.; Breen, G.; Bulik, C. M.; show less...

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