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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04238naa a2200721 4500 | |
| 001 | oai:gup.ub.gu.se/283089 | |
| 003 | SwePub | |
| 008 | 240528s2019 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:141612266 | |
| 024 | 7 | a https://gup.ub.gu.se/publication/2830892 URI |
| 024 | 7 | a https://doi.org/10.1002/pd.55282 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1416122662 URI |
| 040 | a (SwePub)gud (SwePub)ki | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Ericsson, Olle4 aut |
| 245 | 1 0 | a Clinical validation of a novel automated cell-free DNA screening assay for trisomies 21, 13, and 18 in maternal plasma. |
| 264 | c 2019-08-19 | |
| 264 | 1 | b Wiley,c 2019 |
| 520 | a To evaluate clinical performance of a new automated cell-free (cf)DNA assay in maternal plasma screening for trisomies 21, 18, and 13, and to determine fetal sex.Maternal plasma samples from 1200 singleton pregnancies were analyzed with a new non-sequencing cfDNA method, which is based on imaging and counting specific chromosome targets. Reference outcomes were determined by either cytogenetic testing, of amniotic fluid or chorionic villi, or clinical examination of neonates.The samples examined included 158 fetal aneuploidies. Sensitivity was 100% (112/112) for trisomy 21, 89% (32/36) for trisomy 18, and 100% (10/10) for trisomy 13. The respective specificities were 100%, 99.5%, and 99.9%. There were five first pass failures (0.4%), all in unaffected pregnancies. Sex classification was performed on 979 of the samples and 99.6% (975/979) provided a concordant result.The new automated cfDNA assay has high sensitivity and specificity for trisomies 21, 18, and 13 and accurate classification of fetal sex, while maintaining a low failure rate. The study demonstrated that cfDNA testing can be simplified and automated to reduce cost and thereby enabling wider population-based screening. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reproduktionsmedicin och gynekologi0 (SwePub)302202 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Obstetrics, Gynaecology and Reproductive Medicine0 (SwePub)302202 hsv//eng |
| 700 | 1 | a Ahola, Tarja4 aut |
| 700 | 1 | a Dahl, Fredrik4 aut |
| 700 | 1 | a Karlsson, Filip4 aut |
| 700 | 1 | a Persson, Fredrik4 aut |
| 700 | 1 | a Karlberg, Olof4 aut |
| 700 | 1 | a Roos, Fredrik4 aut |
| 700 | 1 | a Alftrén, Ida4 aut |
| 700 | 1 | a Andersson, Björn4 aut |
| 700 | 1 | a Barkenäs, Emelie4 aut |
| 700 | 1 | a Boghos, Ani4 aut |
| 700 | 1 | a Brandner, Birgit4 aut |
| 700 | 1 | a Dahlberg, Jenny4 aut |
| 700 | 1 | a Forsgren, Per-Ola4 aut |
| 700 | 1 | a Francois, Niels4 aut |
| 700 | 1 | a Gousseva, Anna4 aut |
| 700 | 1 | a Hakamali, Faizan4 aut |
| 700 | 1 | a Janfalk-Carlsson, Åsa4 aut |
| 700 | 1 | a Johansson, Henrik4 aut |
| 700 | 1 | a Lundgren, Johanna4 aut |
| 700 | 1 | a Mohsenchian, Atefeh4 aut |
| 700 | 1 | a Olausson, Linus4 aut |
| 700 | 1 | a Olofsson, Simon4 aut |
| 700 | 1 | a Qureshi, Atif4 aut |
| 700 | 1 | a Skarpås, Björn4 aut |
| 700 | 1 | a Svahn, Peter4 aut |
| 700 | 1 | a Sävneby, Anna4 aut |
| 700 | 1 | a Åström, Eva4 aut |
| 700 | 1 | a Sahlberg, Anna4 aut |
| 700 | 1 | a Fianu-Jonasson, Ainou Karolinska Institutet4 aut |
| 700 | 1 | a Gautier, Jérémie4 aut |
| 700 | 1 | a Costa, Jean-Marc4 aut |
| 700 | 1 | a Jacobsson, Bo,d 1960u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology4 aut0 (Swepub:gu)xjacbo |
| 700 | 1 | a Nicolaides, Kypros4 aut |
| 710 | 2 | a Karolinska Institutetb Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi4 org |
| 773 | 0 | t Prenatal diagnosisd : Wileyg 39:11, s. 1011-1015q 39:11<1011-1015x 1097-0223x 0197-3851 |
| 856 | 4 | u https://obgyn.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pd.5528 |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/283089 |
| 856 | 4 8 | u https://doi.org/10.1002/pd.5528 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:141612266 |
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