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Hyperlipidaemia pre...
Hyperlipidaemia prevalence and cholesterol control in obstructive sleep apnoea: Data from the European sleep apnea database (ESADA)
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Gunduz, C. (author)
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Basoglu, O. K. (author)
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- Hedner, Jan A, 1953 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine
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Bonsignore, M. R. (author)
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Hein, H. (author)
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Staats, R. (author)
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Bouloukaki, I. (author)
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Roisman, G. (author)
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Pataka, A. (author)
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Sliwinski, P. (author)
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Ludka, O. (author)
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Pepin, J. L. (author)
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Grote, L. (author)
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Steiropoulos, P. (author)
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Verbraecken, J. (author)
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Petiet, E. (author)
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Trakada, G. (author)
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Montserrat, J. M. (author)
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Fietze, I. (author)
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Penzel, T. (author)
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Ondrej, L. (author)
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Rodenstein, D. (author)
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Masa, J. F. (author)
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Bouloukaki, I. (author)
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Schiza, S. (author)
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Kent, B. (author)
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McNicholas, W. T. (author)
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Ryan, S. (author)
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Riha, R. L. (author)
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Kvamme, J. A. (author)
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Schulz, R. (author)
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Grote, L. (author)
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Hedner, J. (author)
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Zou, D. (author)
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Pepina, J. L. (author)
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Levy, P. (author)
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Bailly, S. (author)
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Lavie, L. (author)
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Lavie, P. (author)
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Hein, H. (author)
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Basoglu, O. K. (author)
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Tasbakan, M. S. (author)
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Varoneckas, G. (author)
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Joppa, P. (author)
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Tkacova, R. (author)
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Staats, R. (author)
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Barbe, F. (author)
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Lombardi, C. (author)
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Parati, G. (author)
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Drummond, M. (author)
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van Zeller, M. (author)
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Bonsignore, M. R. (author)
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Marrone, O. (author)
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Petitjean, M. (author)
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Roisman, G. (author)
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Pretl, M. (author)
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Vitols, A. (author)
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Dogas, Z. (author)
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Galic, T. (author)
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Pataka, A. (author)
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Anttalainen, U. (author)
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Saaresranta, T. (author)
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Plywaczewski, R. (author)
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Sliwinski, P. (author)
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Bielicki, P. (author)
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(creator_code:org_t)
- 2019-07-25
- 2019
- English.
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In: Journal of Internal Medicine. - : Wiley. - 0954-6820 .- 1365-2796. ; 286:6, s. 676-688
- Related links:
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https://repository.u...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Background and objective Obstructive sleep apnoea (OSA) and hyperlipidaemia are independent risk factors for cardiovascular disease. This study investigates the association between OSA and prevalence of hyperlipidaemia in patients of the European Sleep Apnea Database (ESADA) cohort. Methods The cross-sectional analysis included 11 892 patients (age 51.9 +/- 12.5 years, 70% male, body mass index (BMI) 31.3 +/- 6.6 kg/m(2), mean oxygen desaturation index (ODI) 23.7 +/- 25.5 events/h) investigated for OSA. The independent odds ratio (OR) for hyperlipidaemia in relation to measures of OSA (ODI, apnoea-hypopnoea index, mean and lowest oxygen saturation) was determined by means of general linear model analysis with adjustment for important confounders such as age, BMI, comorbidities and study site. Results Hyperlipidaemia prevalence increased from 15.1% in subjects without OSA to 26.1% in those with severe OSA, P < 0.001. Corresponding numbers in patients with diabetes were 8.5% and 41.5%, P < 0.001. Compared with ODI quartile I, patients in ODI quartiles II-IV had an adjusted OR (95% CI) of 1.33 (1.15-1.55), 1.37 (1.17-1.61) and 1.33 (1.12-1.58) (P < 0.001), respectively, for hyperlipidaemia. Obesity was defined as a significant risk factor for hyperlipidaemia. Subgroups of OSA patients with cardio-metabolic comorbidities demonstrated higher prevalence of HL. In addition, differences in hyperlipidaemia prevalence were reported in European geographical regions with the highest prevalence in Central Europe. Conclusion Obstructive sleep apnoea, in particular intermittent hypoxia, was independently associated with the prevalence of hyperlipidaemia diagnosis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- cholesterol
- hyperlipidaemia
- hypoxia
- obesity
- sleep apnoea
- positive airway pressure
- risk-factors
- consequences
- population
- severity
- obesity
- disease
- General & Internal Medicine
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Gunduz, C.
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Basoglu, O. K.
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Hedner, Jan A, 1 ...
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Bonsignore, M. R ...
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Hein, H.
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Staats, R.
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show more...
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Bouloukaki, I.
-
Roisman, G.
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Pataka, A.
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Sliwinski, P.
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Ludka, O.
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Pepin, J. L.
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Grote, L.
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Steiropoulos, P.
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Verbraecken, J.
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Petiet, E.
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Trakada, G.
-
Montserrat, J. M ...
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Fietze, I.
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Penzel, T.
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Ondrej, L.
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Rodenstein, D.
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Masa, J. F.
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Schiza, S.
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Kent, B.
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McNicholas, W. T ...
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Ryan, S.
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Riha, R. L.
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Kvamme, J. A.
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Schulz, R.
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Hedner, J.
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Zou, D.
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Pepina, J. L.
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Levy, P.
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Bailly, S.
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Lavie, L.
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Lavie, P.
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Tasbakan, M. S.
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Varoneckas, G.
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Joppa, P.
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Tkacova, R.
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Barbe, F.
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Lombardi, C.
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Parati, G.
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Drummond, M.
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van Zeller, M.
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Marrone, O.
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Petitjean, M.
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Pretl, M.
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Vitols, A.
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Dogas, Z.
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Galic, T.
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Anttalainen, U.
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Saaresranta, T.
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Plywaczewski, R.
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Bielicki, P.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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Journal of Inter ...
- By the university
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University of Gothenburg