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Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior
- Ganna, A. (author)
- Verweij, K. J. H. (author)
- Nivard, M. G. (author)
- show more...
- Maier, R. (author)
- Wedow, R. (author)
- Busch, A. S. (author)
- Abdellaoui, A. (author)
- Guo, S. (author)
- Sathirapongsasuti, J. F. (author)
- Auton, A. (author)
- Harris, K. M. (author)
- Beecham, G. W. (author)
- Martin, E. R. (author)
- Sanders, A. R. (author)
- Perry, J. R. B. (author)
- Neale, B. M. (author)
- Zietsch, B. P. (author)
- Agee, M. (author)
- Alipanahi, B. (author)
- Auton, A. (author)
- Bell, R. K. (author)
- Bryc, K. (author)
- Elson, S. L. (author)
- Fontanillas, P. (author)
- Furlotte, N. A. (author)
- Hicks, B. (author)
- Huber, K. E. (author)
- Jewett, E. M. (author)
- Jiang, Y. (author)
- Kleinman, A. (author)
- Lin, K. H. (author)
- Litterman, N. K. (author)
- McCreight, J. C. (author)
- McIntyre, M. H. (author)
- McManus, K. F. (author)
- Mountain, J. L. (author)
- Noblin, E. S. (author)
- Northover, C. A. M. (author)
- Pitts, S. J. (author)
- Poznik, G. D. (author)
- Shastri, A. J. (author)
- Shelton, J. F. (author)
- Shringarpure, S. (author)
- Tian, C. (author)
- Tung, J. Y. (author)
- Vacic, V. (author)
- Wang, X. (author)
- Wilson, C. H. (author)
- show less...
- (creator_code:org_t)
- American Association for the Advancement of Science (AAAS), 2019
- 2019
- English.
- In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 365:6456
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Twin and family studies have shown that same-sex sexual behavior is partly genetically influenced, but previous searches for specific genes involved have been underpowered. We performed a genome-wide association study (GWAS) on 477,522 individuals, revealing five loci significantly associated with same-sex sexual behavior. In aggregate, all tested genetic variants accounted for 8 to 25% of variation in same-sex sexual behavior, only partially overlapped between males and females, and do not allow meaningful prediction of an individual's sexual behavior. Comparing these GWAS results with those for the proportion of same-sex to total number of sexual partners among nonheterosexuals suggests that there is no single continuum from opposite-sex to same-sex sexual behavior. Overall, our findings provide insights into the genetics underlying same-sex sexual behavior and underscore the complexity of sexuality.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Keyword
- genome-wide association
- psychiatric-disorders
- general-population
- orientation
- linkage
- disease
- loci
- schizophrenia
- trait
- homosexuality
- Science & Technology - Other Topics
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
- Ganna, A.
- Verweij, K. J. H ...
- Nivard, M. G.
- Maier, R.
- Wedow, R.
- Busch, A. S.
- show more...
- Abdellaoui, A.
- Guo, S.
- Sathirapongsasut ...
- Lichtenstein, P.
- Lundström, Sebas ...
- Langstrom, N.
- Auton, A.
- Harris, K. M.
- Beecham, G. W.
- Martin, E. R.
- Sanders, A. R.
- Perry, J. R. B.
- Neale, B. M.
- Zietsch, B. P.
- Agee, M.
- Alipanahi, B.
- Bell, R. K.
- Bryc, K.
- Elson, S. L.
- Fontanillas, P.
- Furlotte, N. A.
- Hicks, B.
- Huber, K. E.
- Jewett, E. M.
- Jiang, Y.
- Kleinman, A.
- Lin, K. H.
- Litterman, N. K.
- McCreight, J. C.
- McIntyre, M. H.
- McManus, K. F.
- Mountain, J. L.
- Noblin, E. S.
- Northover, C. A. ...
- Pitts, S. J.
- Poznik, G. D.
- Shastri, A. J.
- Shelton, J. F.
- Shringarpure, S.
- Tian, C.
- Tung, J. Y.
- Vacic, V.
- Wang, X.
- Wilson, C. H.
- show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Medical Genetics
- Articles in the publication
- Science
- By the university
- University of Gothenburg
- Karolinska Institutet
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