Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior

Twin and family studies have shown that same-sex sexual behavior is partly genetically influenced, but previous searches for specific genes involved have been underpowered. We performed a genome-wide association study (GWAS) on 477,522 individuals, revealing five loci significantly associated with same-sex sexual behavior. In aggregate, all tested genetic variants accounted for 8 to 25% of variation in same-sex sexual behavior, only partially overlapped between males and females, and do not allow meaningful prediction of an individual's sexual behavior. Comparing these GWAS results with those for the proportion of same-sex to total number of sexual partners among nonheterosexuals suggests that there is no single continuum from opposite-sex to same-sex sexual behavior. Overall, our findings provide insights into the genetics underlying same-sex sexual behavior and underscore the complexity of sexuality.

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Medicinsk genetik hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Medical Genetics hsv//eng
genome-wide association
psychiatric-disorders
general-population
orientation
linkage
disease
loci
schizophrenia
trait
homosexuality
Science & Technology - Other Topics

Verweij, K. J. H. (author)
Nivard, M. G. (author)
Maier, R. (author)
Wedow, R. (author)
Busch, A. S. (author)
Abdellaoui, A. (author)
Guo, S. (author)
Sathirapongsasuti, J. F. (author)
Lichtenstein, P.Karolinska Institutet (author)
Lundström, SebastianGothenburg University,Göteborgs universitet,Gillbergcentrum,Centrum för etik, juridik och mental hälsa,Gillberg Neuropsychiatry Centre,Centre for Ethics, Law, and Mental Health(Swepub:gu)xluseb (author)
Langstrom, N.Karolinska Institutet (author)
Auton, A. (author)
Harris, K. M. (author)
Beecham, G. W. (author)
Martin, E. R. (author)
Sanders, A. R. (author)
Perry, J. R. B. (author)
Neale, B. M. (author)
Zietsch, B. P. (author)
Agee, M. (author)
Alipanahi, B. (author)
Auton, A. (author)
Bell, R. K. (author)
Bryc, K. (author)
Elson, S. L. (author)
Fontanillas, P. (author)
Furlotte, N. A. (author)
Hicks, B. (author)
Huber, K. E. (author)
Jewett, E. M. (author)
Jiang, Y. (author)
Kleinman, A. (author)
Lin, K. H. (author)
Litterman, N. K. (author)
McCreight, J. C. (author)
McIntyre, M. H. (author)
McManus, K. F. (author)
Mountain, J. L. (author)
Noblin, E. S. (author)
Northover, C. A. M. (author)
Pitts, S. J. (author)
Poznik, G. D. (author)
Shastri, A. J. (author)
Shelton, J. F. (author)
Shringarpure, S. (author)
Tian, C. (author)
Tung, J. Y. (author)
Vacic, V. (author)
Wang, X. (author)
Wilson, C. H. (author)
Karolinska InstitutetGillbergcentrum (creator_code:org_t)

In:Science: American Association for the Advancement of Science (AAAS)365:64560036-80751095-9203

By the author/editor: Ganna, A.; Verweij, K. J. H ...; Nivard, M. G.; Maier, R.; Wedow, R.; Busch, A. S.; show more...; Abdellaoui, A.; Guo, S.; Sathirapongsasut ...; Lichtenstein, P.; Lundström, Sebas ...; Langstrom, N.; Auton, A.; Harris, K. M.; Beecham, G. W.; Martin, E. R.; Sanders, A. R.; Perry, J. R. B.; Neale, B. M.; Zietsch, B. P.; Agee, M.; Alipanahi, B.; Bell, R. K.; Bryc, K.; Elson, S. L.; Fontanillas, P.; Furlotte, N. A.; Hicks, B.; Huber, K. E.; Jewett, E. M.; Jiang, Y.; Kleinman, A.; Lin, K. H.; Litterman, N. K.; McCreight, J. C.; McIntyre, M. H.; McManus, K. F.; Mountain, J. L.; Noblin, E. S.; Northover, C. A. ...; Pitts, S. J.; Poznik, G. D.; Shastri, A. J.; Shelton, J. F.; Shringarpure, S.; Tian, C.; Tung, J. Y.; Vacic, V.; Wang, X.; Wilson, C. H.; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Medical Genetics

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