Discovery and validation of plasma proteomic biomarkers relating to brain amyloid burden by SOMAscan assay.

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Shi, LiuDepartment of Psychiatry, University of Oxford, Oxford, United Kingdom (author)

Discovery and validation of plasma proteomic biomarkers relating to brain amyloid burden by SOMAscan assay.

Article/chapterEnglish2019

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2019-09-05
Wiley,2019

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LIBRIS-ID:oai:gup.ub.gu.se/284238
https://gup.ub.gu.se/publication/284238URI
https://doi.org/10.1016/j.jalz.2019.06.4951DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-78371URI
http://kipublications.ki.se/Default.aspx?queryparsed=id:142297691URI

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Language:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

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Funding Agencies:Innovative Medicines Initiative Joint Undertaking under EMIF grant 115372European Union (EU)EFPIA companies' European Commission Joint Research Centre QLRT-2001-245537670Stichting voor Alzheimer Onderzoek 11020 13007 15005Department of Health of the Basque Government 17.0.1.08.12.0000.2.454.01.41142.001.HUniversity of Antwerp Research Fund NIHR biomedical research centre at UCLH DPUK through MRC MR/L023784/2Medical Research Council UK (MRC) MC_PC_17215
Plasma proteins have been widely studied as candidate biomarkers to predict brain amyloid deposition to increase recruitment efficiency in secondary prevention clinical trials for Alzheimer's disease. Most such biomarker studies are targeted to specific proteins or are biased toward high abundant proteins.4001 plasma proteins were measured in two groups of participants (discovery group=516, replication group=365) selected from the European Medical Information Framework for Alzheimer's disease Multimodal Biomarker Discovery study, all of whom had measures of amyloid.A panel of proteins (n=44), along with age and apolipoprotein E (APOE) ε4, predicted brain amyloid deposition with good performance in both the discovery group (area under the curve=0.78) and the replication group (area under the curve=0.68). Furthermore, a causal relationship between amyloid and tau was confirmed by Mendelian randomization.The results suggest that high-dimensional plasma protein testing could be a useful and reproducible approach for measuring brain amyloid deposition.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Psykiatri hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Psychiatry hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Neurovetenskaper hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Neurosciences hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Neurologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Neurology hsv//eng
Amyloid beta

Added entries (persons, corporate bodies, meetings, titles ...)

Westwood, Sarah (author)
Baird, Alison L (author)
Winchester, Laura (author)
Dobricic, Valerija (author)
Kilpert, Fabian (author)
Hong, Shengjun (author)
Franke, Andre (author)
Hye, Abdul (author)
Ashton, Nicholas J.Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Wallenberg Centre for Molecular and Translational Medicine,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xashtn (author)
Morgan, Angharad R (author)
Bos, Isabelle (author)
Vos, Stephanie J B (author)
Buckley, Noel J (author)
Kate, Mara Ten (author)
Scheltens, Philip (author)
Vandenberghe, Rik (author)
Gabel, Silvy (author)
Meersmans, Karen (author)
Engelborghs, Sebastiaan (author)
De Roeck, Ellen E (author)
Sleegers, Kristel (author)
Frisoni, Giovanni B (author)
Blin, Olivier (author)
Richardson, Jill C (author)
Bordet, Régis (author)
Molinuevo, José L (author)
Rami, Lorena (author)
Wallin, Anders,1950Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology(Swepub:gu)xwaand (author)
Kettunen, PetronellaGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology(Swepub:gu)xketpe (author)
Tsolaki, Magda (author)
Verhey, Frans (author)
Lleó, Alberto (author)
Alcolea, Daniel (author)
Popp, JuliusKarolinska Institutet (author)
Peyratout, Gwendoline (author)
Martinez-Lage, Pablo (author)
Tainta, Mikel (author)
Johannsen, Peter (author)
Teunissen, Charlotte E (author)
Freund-Levi, Yvonne,1956-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Neurobiology, Caring Sciences and Society (NVS), Division of Clinical Geriatrics, Karolinska Institutet, Department of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden; Department of Psychiatry in Region Örebro County and School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden; Department of Old Age Psychiatry, Psychology and Neuroscience, Kings College London, London, United Kingdom(Swepub:oru)yfi (author)
Frölich, Lutz (author)
Legido-Quigley, Cristina (author)
Barkhof, Frederik (author)
Blennow, Kaj,1958Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xbleka (author)
Zetterberg, Henrik,1973Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xzethe (author)
Baker, Susan (author)
Morgan, B Paul (author)
Streffer, Johannes (author)
Visser, Pieter Jelle (author)
Bertram, Lars (author)
Lovestone, Simon (author)
Nevado-Holgado, Alejo JDepartment of Psychiatry, University of Oxford, Oxford, United Kingdom (author)
Department of Psychiatry, University of Oxford, Oxford, United KingdomInstitutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi (creator_code:org_t)

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By the author/editor: Shi, Liu; Westwood, Sarah; Baird, Alison L; Winchester, Laur ...; Dobricic, Valeri ...; Kilpert, Fabian; show more...; Hong, Shengjun; Franke, Andre; Hye, Abdul; Ashton, Nicholas ...; Morgan, Angharad ...; Bos, Isabelle; Vos, Stephanie J ...; Buckley, Noel J; Kate, Mara Ten; Scheltens, Phili ...; Vandenberghe, Ri ...; Gabel, Silvy; Meersmans, Karen; Engelborghs, Seb ...; De Roeck, Ellen ...; Sleegers, Kriste ...; Frisoni, Giovann ...; Blin, Olivier; Richardson, Jill ...; Bordet, Régis; Molinuevo, José ...; Rami, Lorena; Wallin, Anders, ...; Kettunen, Petron ...; Tsolaki, Magda; Verhey, Frans; Lleó, Alberto; Alcolea, Daniel; Popp, Julius; Peyratout, Gwend ...; Martinez-Lage, P ...; Tainta, Mikel; Johannsen, Peter; Teunissen, Charl ...; Freund-Levi, Yvo ...; Frölich, Lutz; Legido-Quigley, ...; Barkhof, Frederi ...; Blennow, Kaj, 19 ...; Zetterberg, Henr ...; Baker, Susan; Morgan, B Paul; Streffer, Johann ...; Visser, Pieter J ...; Bertram, Lars; Lovestone, Simon; Nevado-Holgado, ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Psychiatry

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Neurosciences

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Neurology

Articles in the publication: Alzheimer's & de ...; Alzheimer's & De ...

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