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Study protocol: ASC...
Study protocol: ASCRIBED: the impact of Acute SystematiC inflammation upon cerebRospinal fluId and blood BiomarkErs of brain inflammation and injury in dementia: a study in acute hip fracture patients
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Leavey, N. (author)
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Hammond, S. P. (author)
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Shepstone, L. (author)
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Cross, J. (author)
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Cunningham, C. (author)
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MacLullich, A. (author)
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Watne, L. O. (author)
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Minihane, A. M. (author)
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Ballard, C. (author)
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Knapskog, A. B. (author)
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Hall, R. (author)
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Howard, G. (author)
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Hammond, M. (author)
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Fox, C. (author)
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(creator_code:org_t)
- 2019-09-07
- 2019
- English.
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In: BMC Neurology. - : Springer Science and Business Media LLC. - 1471-2377. ; 19:1
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https://bmcneurol.bi...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- Background Hip fracture represents a substantial acute inflammatory trauma, which may constitute a significant insult to the degenerating brain. Research suggests that an injury of this kind can affect memory and thinking in the future but it is unclear whether, and how, inflammatory trauma injures the brain. The impact of Acute SystematiC inflammation upon cerebRospinal fluId and blood BiomarkErs of brain inflammation and injury in Dementia: a study in acute hip fracture patients (ASCRIBED) explores this relationship, to understand the effect of inflammation on the progression of dementia. Methods This protocol describes a multi-centre sample collection observational study. The study utilises the unique opportunity provided by hip fracture operations undertaken via spinal anaesthesia to collect cerebrospinal fluid (CSF) and blood, to investigate the impact of acute brain inflammation caused by hip fracture on the exacerbation of dementia. We will recruit 200 hip fracture patients with a diagnosis or evidence of dementia; and 200 hip fracture patients without dementia. We will also recruit 'Suitable informants', individuals in regular contact with the patient, to provide further proxy evidence of a patient's potential cognitive decline. We will compare these 400 samples with existing CSF and blood samples from a cohort of dementia patients who had not experienced a systemic inflammatory response due to injury. This will provide a comparison between patients with and without dementia who are suffering a systemic inflammatory response; with stable patients living with dementia. Discussion We will test the hypothesis that hip fracture patients living with dementia show elevated markers of brain inflammation, as well as neuronal injury and Alzheimer-related plaque pathology, in comparison to (1) stable patients living with dementia and (2) hip fracture patients without dementia, as measured by biomarkers in CSF and blood. The findings will address the hypothesis that systemic inflammatory events can exacerbate underlying dementia and inform the search for new treatments targeting inflammation in dementia.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Dementia
- Hip fracture
- Inflammation
- Cerebrospinal fluid
- alzheimers-disease
- cognitive decline
- informant questionnaire
- elderly
- iqcode
- risk-factor
- delirium
- Neurosciences & Neurology
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Leavey, N.
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Hammond, S. P.
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Shepstone, L.
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Cross, J.
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Zetterberg, Henr ...
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Cunningham, C.
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show more...
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MacLullich, A.
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Watne, L. O.
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Minihane, A. M.
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Ballard, C.
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Knapskog, A. B.
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Hall, R.
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Howard, G.
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Hammond, M.
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Fox, C.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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BMC Neurology
- By the university
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University of Gothenburg