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Intestinal developm...
Intestinal development and homeostasis require activation and apoptosis of diet-reactive T cells
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Visekruna, A. (author)
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Hartmann, S. (author)
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Sillke, Y. R. (author)
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Glauben, R. (author)
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Fischer, F. (author)
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Raifer, H. (author)
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Mollenkopf, H. (author)
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Bertrams, W. (author)
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Schmeck, B. (author)
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Klein, M. (author)
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Pagenstecher, A. (author)
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Lohoff, M. (author)
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Jacob, R. (author)
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Pabst, O. (author)
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- Bland, Paul William, 1949 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology
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Luu, M. (author)
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Romero, R. (author)
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Siegmund, B. (author)
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Rajalingam, K. (author)
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Steinhoff, U. (author)
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(creator_code:org_t)
- 2019
- 2019
- English.
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In: The Journal of clinical investigation. - 1558-8238. ; 129:5, s. 1972-1983
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Abstract
Subject headings
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- The impact of food antigens on intestinal homeostasis and immune function is poorly understood. Here, we explored the impact of dietary antigens on the phenotype and fate of intestinal T cells. Physiological uptake of dietary proteins generated a highly activated CD44+Helios+CD4+ T cell population predominantly in Peyer patches. These cells are distinct from regulatory T cells and develop independently of the microbiota. Alimentation with a protein-free, elemental diet led to an atrophic small intestine with low numbers of activated T cells, including Tfh cells and decreased amounts of intestinal IgA and IL-10. Food-activated CD44+Helios+CD4+ T cells in the Peyer patches are controlled by the immune checkpoint molecule PD-1. Blocking the PD-1 pathway rescued these T cells from apoptosis and triggered proinflammatory cytokine production, which in IL-10-deficient mice was associated with intestinal inflammation. In support of these findings, our study of patients with Crohn's disease revealed significantly reduced frequencies of apoptotic CD4+ T cells in Peyer patches as compared with healthy controls. These results suggest that apoptosis of diet-activated T cells is a hallmark of the healthy intestine.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Keyword
- Gastroenterology
- Homeostasis
- Immunology
- Inflammatory bowel disease
- T cells
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Visekruna, A.
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Hartmann, S.
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Sillke, Y. R.
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Glauben, R.
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Fischer, F.
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Raifer, H.
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show more...
-
Mollenkopf, H.
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Bertrams, W.
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Schmeck, B.
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Klein, M.
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Pagenstecher, A.
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Lohoff, M.
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Jacob, R.
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Pabst, O.
-
Bland, Paul Will ...
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Luu, M.
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Romero, R.
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Siegmund, B.
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Rajalingam, K.
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Steinhoff, U.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Gastroenterology ...
- Articles in the publication
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The Journal of c ...
- By the university
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University of Gothenburg