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Pollen exposure wea...
Pollen exposure weakens innate defense against respiratory viruses.
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Gilles, Stefanie (author)
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Blume, Cornelia (author)
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Wimmer, Maria (author)
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Damialis, Athanasios (author)
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Meulenbroek, Laura (author)
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Gökkaya, Mehmet (author)
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Bergougnan, Carolin (author)
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Eisenbart, Selina (author)
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- Sundell, Nicklas (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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- Lindh, Magnus, 1960 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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- Andersson, Lars-Magnus, 1968 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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- Dahl, Åslög, 1955 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biologi och miljövetenskap,Department of Biological and Environmental Sciences
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Chaker, Adam (author)
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Häring, Franziska (author)
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Wagner, Sabrina (author)
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Neumann, Avidan U (author)
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Akdis, Cezmi A (author)
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Garssen, Johan (author)
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- Westin, Johan, 1965 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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Vanˊt Land, Belinda (author)
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Davies, Donna E (author)
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Traidl-Hoffmann, Claudia (author)
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(creator_code:org_t)
- 2019-11-07
- 2020
- English.
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In: Allergy. - : Wiley. - 1398-9995 .- 0105-4538. ; 75:3, s. 576-587
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Abstract
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- Hundreds of plant species release their pollen into the air every year during early spring. During that period, pollen allergic as well as non-allergic patients frequently present to doctors with severe respiratory tract infections.To assess whether pollen may interfere with antiviral immunity.We combined data from real life human exposure cohorts, a mouse model and human cell culture to test our hypothesis.Pollen significantly diminished interferon-λ and pro-inflammatory chemokine responses of airway epithelia to rhinovirus and viral mimics and decreased nuclear translocation of interferon regulatory factors. In mice infected with respiratory syncytial virus, co-exposure to pollen caused attenuated antiviral gene expression and increased pulmonary viral titers. In non-allergic human volunteers, nasal symptoms were positively correlated with airborne birch pollen abundance, and nasal birch pollen challenge led to down-regulation of type I and -III interferons in nasal mucosa. In a large patient cohort, numbers of rhinovirus-positive cases were correlated with airborne birch pollen concentrations.The ability of pollen to suppress innate antiviral immunity, independent of allergy, suggests that high-risk population groups should avoid extensive outdoor activities when pollen and respiratory virus seasons coincide.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
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- ref (subject category)
- art (subject category)
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Allergy
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To the university's database
- By the author/editor
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Gilles, Stefanie
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Blume, Cornelia
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Wimmer, Maria
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Damialis, Athana ...
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Meulenbroek, Lau ...
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Gökkaya, Mehmet
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show more...
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Bergougnan, Caro ...
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Eisenbart, Selin ...
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Sundell, Nicklas
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Lindh, Magnus, 1 ...
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Andersson, Lars- ...
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Dahl, Åslög, 195 ...
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Chaker, Adam
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Häring, Franzisk ...
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Wagner, Sabrina
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Neumann, Avidan ...
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Akdis, Cezmi A
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Garssen, Johan
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Westin, Johan, 1 ...
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Vanˊt Land, Beli ...
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Davies, Donna E
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Traidl-Hoffmann, ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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Allergy
- By the university
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University of Gothenburg