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Postprandial levels...
Postprandial levels of GLP-1, GIP and glucagon after 2 years of weight loss with a Paleolithic diet: A randomised controlled trial in healthy obese women
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- Otten, Julia, 1973- (author)
- Umeå universitet,Avdelningen för medicin
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- Ryberg, Mats (author)
- Umeå universitet,Avdelningen för medicin
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- Mellberg, Caroline (author)
- Umeå universitet,Avdelningen för medicin
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- Andersson, T. (author)
- Umeå universitet,Avdelningen för medicin
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- Chorell, Elin, 1981- (author)
- Umeå universitet,Avdelningen för medicin
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- Lindahl, Bernt (author)
- Umeå universitet,Avdelningen för hållbar hälsa
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- Larsson, Christel, 1972 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kost- och idrottsvetenskap,Department of Food and Nutrition, and Sport Science,Department of Food and Nutrition, and Sport Science, Goteborgs Universitet, Goteborg, Sweden
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Holst, J. J. (author)
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- Olsson, Tommy (author)
- Umeå universitet,Avdelningen för medicin
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(creator_code:org_t)
- Bioscientifica, 2019
- 2019
- English.
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In: European Journal of Endocrinology. - : Bioscientifica. - 0804-4643 .- 1479-683X. ; 180:6, s. 417-427
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Abstract
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- Objective: To investigate how weight loss by different diets impacts postp randial levels of glucagon-like peptide 1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP) and glucagon. Methods: In this single-centre, parallel group 2-year trial, 70 healthy postmenopausal obese women were randomised to the Paleolithic diet or a healthy control diet based on Nordic Nutrition Recommendations. Both diets were without calorie restriction. The primary outcome was the change in fat mass. Here, secondary analyses on GLP-1, GIP and glucagon measured during an OGTT are described. Results: In the Paleolithic diet group, mean weight loss compared to ba seline was 11% at 6 months and 10% at 24 months. In the control diet group, mean weight loss was 6% a fter 6 and 24 months (P = 0.0001 and P = 0.049 for the comparison between groups at 6 and 24 months respectively). Compared to baseline, the mean incremental area under the curve (iAUC) for GLP-1 increased by 34 and 45% after 6 and 24 months in the Paleolithic diet group and increased by 59% after 24 months in the control diet group. The mean iAUC for GIP increased only in the Paleolithic diet group. The area under the curve (AUC) for glucagon increas ed during the first 6 months in both groups. The fasting glucagon increase correlated with the β-hydroxybutyrate increase. Conclusions: Weight loss caused an increase in postprandial GLP-1 levels and a further rise occurred during weight maintenance. Postprandial GIP levels increased only after the Paleolithic diet. Reduced postprandial glucagon suppression may be caused by a catabolic state. © 2019 European Society of Endocrinology Printed in Great Britain.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- 3 hydroxybutyric acid
- fatty acid
- gastric inhibitory polypeptide
- glucagon
- glucagon like peptide 1
- glucose
- incretin
- insulin
- biological marker
- adult
- Article
- body weight
- body weight loss
- caloric intake
- caloric restriction
- carbohydrate intake
- carboxy terminal sequence
- comparative study
- controlled study
- diet therapy
- dietary compliance
- dual energy X ray absorptiometry
- fat intake
- fat mass
- female
- gas chromatography
- glucose blood level
- human
- insulin blood level
- major clinical study
- middle aged
- nitrogen urine level
- obese patient
- obesity
- oral glucose tolerance test
- paleolithic diet
- postmenopause
- postprandial state
- priority journal
- protein intake
- randomized controlled trial
- treatment outcome
- aged
- blood
- physiology
- Biomarkers
- Diet
- Paleolithic
- Energy Intake
- Glucagon-Like Peptide 1
- Humans
- Postprandial Period
- Weight Loss
- glucagon
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Otten, Julia, 19 ...
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Ryberg, Mats
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Mellberg, Caroli ...
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Andersson, T.
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Chorell, Elin, 1 ...
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Lindahl, Bernt
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Larsson, Christe ...
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Holst, J. J.
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Olsson, Tommy
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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European Journal ...
- By the university
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University of Gothenburg
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Umeå University