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Protocol Introducin...
Protocol Introducing a New Algorithm for Classification of Etiology in Studies on Pediatric Pneumonia: Protocol for the Trial of Respiratory Infections in Children for Enhanced Diagnostics Study
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- Rhedin, S. A. (author)
- Karolinska Institutet,South Gen Hosp, Sachs Children & Youth Hosp, Hjalmar Cederstroms Gata 14, S-11861 Stockholm, Sweden;Karolinska Insitutet, Dept Med Epidemiol & Biostat, Stockholm, Sweden
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- Eklundh, A. (author)
- Karolinska Institutet,South Gen Hosp, Sachs Children & Youth Hosp, Hjalmar Cederstroms Gata 14, S-11861 Stockholm, Sweden
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- Ryd-Rinder, M. (author)
- Karolinska Institutet,Astrid Lindgren Childrens Hosp, Stockholm, Sweden
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- Naucler, P. (author)
- Karolinska Institutet,Karolinska Inst, Dept Med, Div Infect Dis, Stockholm, Sweden;Karolinska Univ Hosp, Dept Infect Dis, Stockholm, Sweden
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- Mårtensson, Andreas, 1963- (author)
- Uppsala universitet,Internationell barnhälsa och nutrition
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- Gantelius, Jesper (author)
- KTH,Nanobioteknologi,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Div Prote & Nanobiotechnol, Sci Life Lab, Stockholm, Sweden
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- Zenk, I. (author)
- South Gen Hosp, Sachs Children & Youth Hosp, Hjalmar Cederstroms Gata 14, S-11861 Stockholm, Sweden
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- Svahn Andersson, Helene (author)
- KTH,Science for Life Laboratory, SciLifeLab,Nanobioteknologi,KTH Royal Inst Technol, Div Prote & Nanobiotechnol, Sci Life Lab, Stockholm, Sweden
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- Nybond, Susanna (author)
- KTH,Nanobioteknologi,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Div Prote & Nanobiotechnol, Sci Life Lab, Stockholm, Sweden
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- Rasti, R. (author)
- Karolinska Institutet,South Gen Hosp, Sachs Children & Youth Hosp, Hjalmar Cederstroms Gata 14, S-11861 Stockholm, Sweden;Karolinska Inst, Dept Publ Hlth Sci, Stockholm, Sweden
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- Lindh, Magnus, 1960 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,Univ Gothenburg, Dept Infect Dis, Gothenburg, Sweden
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- Andersson, Maria (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,Univ Gothenburg, Dept Infect Dis, Gothenburg, Sweden
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- Peltola, V. (author)
- Turku Univ Hosp, Dept Paediat & Adolescent Med, Turku, Finland;Univ Turku, Turku, Finland
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- Waris, M. (author)
- Turku Univ Hosp, Dept Paediat & Adolescent Med, Turku, Finland;Univ Turku, Turku, Finland
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- Alfvén, T. (author)
- Karolinska Institutet,South Gen Hosp, Sachs Children & Youth Hosp, Hjalmar Cederstroms Gata 14, S-11861 Stockholm, Sweden;Karolinska Inst, Dept Publ Hlth Sci, Stockholm, Sweden
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(creator_code:org_t)
- 2019-04-26
- 2019
- English.
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In: Journal of Medical Internet Research. - : JMIR Publications Inc.. - 1438-8871. ; 21:4
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https://gup.ub.gu.se...
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Abstract
Subject headings
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- Background: There is a need to better distinguish viral infections from antibiotic-requiring bacterial infections in children presenting with clinical community-acquired pneumonia (CAP) to assist health care workers in decision making and to improve the rational use of antibiotics. Objective: The overall aim of the Trial of Respiratory infections in children for ENhanced Diagnostics (TREND) study is to improve the differential diagnosis of bacterial and viral etiologies in children aged below 5 years with clinical CAP, by evaluating myxovirus resistance protein A (MxA) as a biomarker for viral CAP and by evaluating an existing (multianalyte point-of-care antigen detection test system [mariPOC respi] ArcDia International Oy Ltd.) and a potential future point-of-care test for respiratory pathogens. Methods: Children aged 1 to 59 months with clinical CAP as well as healthy, hospital-based, asymptomatic controls will be included at a pediatric emergency hospital in Stockholm, Sweden. Blood (analyzed for MxA and C-reactive protein) and nasopharyngeal samples (analyzed with real-time polymerase chain reaction as the gold standard and antigen-based mariPOC respi test as well as saved for future analyses of a novel recombinase polymerase amplification-based point-of-care test for respiratory pathogens) will be collected. A newly developed algorithm for the classification of CAP etiology will be used as the reference standard. Results: A pilot study was performed from June to August 2017. The enrollment of study subjects started in November 2017. Results are expected by the end of 2019.Conclusions: The findings from the TREND study can be an important step to improve the management of children with clinical. © 2019 Journal of Medical Internet Research. All rights reserved.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Keyword
- Child
- preschool
- Diagnostic tests
- routine
- Microbiological techniques
- Pneumonia
- Respiratory tract infections
- Child
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Rhedin, S. A.
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Eklundh, A.
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Ryd-Rinder, M.
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Naucler, P.
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Mårtensson, Andr ...
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Gantelius, Jespe ...
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show more...
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Zenk, I.
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Svahn Andersson, ...
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Nybond, Susanna
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Rasti, R.
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Lindh, Magnus, 1 ...
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Andersson, Maria
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Peltola, V.
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Waris, M.
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Alfvén, T.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Pediatrics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Infectious Medic ...
- Articles in the publication
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Journal of Medic ...
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JMIR Research Pr ...
- By the university
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University of Gothenburg
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Royal Institute of Technology
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Karolinska Institutet
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Uppsala University