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Attention-deficit h...
Attention-deficit hyperactivity disorder shares copy number variant risk with schizophrenia and autism spectrum disorder
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Gudmundsson, O. O. (author)
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Walters, G. B. (author)
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Ingason, A. (author)
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Johansson, S. (author)
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Zayats, T. (author)
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Athanasiu, L. (author)
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Sonderby, I. E. (author)
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Gustafsson, O. (author)
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Nawaz, M. S. (author)
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Jonsson, G. F. (author)
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- Jonsson, Lina, 1982 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Neuroscience and Physiology, Department of Pharmacology
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Knappskog, P. M. (author)
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Ingvarsdottir, E. (author)
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Davidsdottir, K. (author)
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Djurovic, S. (author)
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Knudsen, G. P. S. (author)
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Askeland, R. B. (author)
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Haraldsdottir, G. S. (author)
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Baldursson, G. (author)
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Magnusson, P. (author)
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Sigurdsson, E. (author)
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Gudbjartsson, D. F. (author)
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Stefansson, H. (author)
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Andreassen, O. A. (author)
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Haavik, J. (author)
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Reichborn-Kjennerud, T. (author)
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Stefansson, K. (author)
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(creator_code:org_t)
- 2019-10-17
- 2019
- English.
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In: Translational Psychiatry. - : Springer Science and Business Media LLC. - 2158-3188. ; 9
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https://www.nature.c...
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https://gup.ub.gu.se...
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Abstract
Subject headings
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- Attention-deficit/hyperactivity disorder (ADHD) is a highly heritable common childhood-onset neurodevelopmental disorder. Some rare copy number variations (CNVs) affect multiple neurodevelopmental disorders such as intellectual disability, autism spectrum disorders (ASD), schizophrenia and ADHD. The aim of this study is to determine to what extent ADHD shares high risk CNV alleles with schizophrenia and ASD. We compiled 19 neuropsychiatric CNVs and test 14, with sufficient power, for association with ADHD in Icelandic and Norwegian samples. Eight associate with ADHD; deletions at 2p16.3 (NRXN1), 15q11.2, 15q13.3 (BP4 & BP4.5–BP5) and 22q11.21, and duplications at 1q21.1 distal, 16p11.2 proximal, 16p13.11 and 22q11.21. Six of the CNVs have not been associated with ADHD before. As a group, the 19 CNVs associate with ADHD (OR=2.43, P=1.6×10−21), even when comorbid ASD and schizophrenia are excluded from the sample. These results highlight the pleiotropic effect of the neuropsychiatric CNVs and add evidence for ADHD, ASD and schizophrenia being related neurodevelopmental disorders rather than distinct entities.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Keyword
- deficit/hyperactivity disorder
- psychiatric-disorders
- 22q11.2 deletion
- norwegian mother
- cohort profile
- child cohort
- duplications
- phenotype
- genetics
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Gudmundsson, O. ...
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Walters, G. B.
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Ingason, A.
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Johansson, S.
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Zayats, T.
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Athanasiu, L.
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show more...
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Sonderby, I. E.
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Gustafsson, O.
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Nawaz, M. S.
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Jonsson, G. F.
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Jonsson, Lina, 1 ...
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Knappskog, P. M.
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Ingvarsdottir, E ...
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Davidsdottir, K.
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Djurovic, S.
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Knudsen, G. P. S ...
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Askeland, R. B.
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Haraldsdottir, G ...
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Baldursson, G.
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Magnusson, P.
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Sigurdsson, E.
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Gudbjartsson, D. ...
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Stefansson, H.
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Andreassen, O. A ...
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Haavik, J.
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Reichborn-Kjenne ...
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Stefansson, K.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
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Translational Ps ...
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University of Gothenburg