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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04171naa a2200613 4500 | |
| 001 | oai:gup.ub.gu.se/285373 | |
| 003 | SwePub | |
| 008 | 240528s2020 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:141991367 | |
| 024 | 7 | a https://gup.ub.gu.se/publication/2853732 URI |
| 024 | 7 | a https://doi.org/10.1111/joim.129762 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1419913672 URI |
| 040 | a (SwePub)gud (SwePub)ki | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Cederstrom, S.u Karolinska Institutet4 aut |
| 245 | 1 0 | a New candidate genes for ST-elevation myocardial infarction |
| 264 | c 2019-10-07 | |
| 264 | 1 | b Wiley,c 2020 |
| 520 | a Background Despite extensive research in atherosclerosis, the mechanisms of coronary atherothrombosis in ST-elevation myocardial infarction (STEMI) patients are undetermined. Objectives Our aim was to find candidate genes involved in STEMI by analysing leucocyte gene expression in STEMI patients, without the influence of secondary inflammation from innate immunity, which was assumed to be a consequence rather than the cause of coronary atherothrombosis. Methods Fifty-one patients were included at coronary angiography because of STEMI. Arterial blood was sampled in the acute phase (P1), at 24-48 h (P2) and at 3 months (P3). Leucocyte RNA was isolated and gene expression analysis was performed by Affymetrix Human Transcriptome Array 2.0. By omission of up- or downregulated genes at P2, secondary changes from innate immunity were excluded. Genes differentially expressed in P1 when compared to the convalescent sample in P3 were determined as genes involved in STEMI. Results Three genes were upregulated at P1 compared to P3; ABCG1 (P = 5.81 x 10(-5)), RAB20 (P = 3.69 x 10(-5)) and TMEM2 (P = 7.75 x 10(-6)) whilst four were downregulated; ACVR1 (P = 9.01 x 10(-5)), NFATC2IP (P = 8.86 x 10(-5)), SUN1 (P = 3.87 x 10(-5)) and TTC9C (P = 7.18 x 10(-6)). These genes were also highly expressed in carotid atherosclerotic plaques. Conclusions We found seven genes involved in STEMI. The study is unique regarding the blood sampling in the acute phase and omission of secondary expressed genes from innate immunity. However, the results need to be replicated by future studies. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng |
| 653 | a acute myocardial infarction | |
| 653 | a atherothrombosis | |
| 653 | a cardiovascular clinical research | |
| 653 | a plaque rupture | |
| 653 | a cholesterol efflux | |
| 653 | a kappa-b | |
| 653 | a abcg1 | |
| 653 | a atherosclerosis | |
| 653 | a expression | |
| 653 | a receptor | |
| 653 | a mice | |
| 653 | a inflammation | |
| 653 | a deficiency | |
| 653 | a statins | |
| 653 | a General & Internal Medicine | |
| 700 | 1 | a Lundman, P.u Karolinska Institutet4 aut |
| 700 | 1 | a Folkersen, L.4 aut |
| 700 | 1 | a Paulsson-Berne, G.u Karolinska Institutet4 aut |
| 700 | 1 | a Karadimou, G.u Karolinska Institutet4 aut |
| 700 | 1 | a Eriksson, P.u Karolinska Institutet4 aut |
| 700 | 1 | a Caidahl, Kenneth,d 1949u Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut0 (Swepub:gu)xcaike |
| 700 | 1 | a Gabrielsen, A.u Karolinska Institutet4 aut |
| 700 | 1 | a Jernberg, T.u Karolinska Institutet4 aut |
| 700 | 1 | a Persson, J.u Karolinska Institutet4 aut |
| 700 | 1 | a Tornvall, P.u Karolinska Institutet4 aut |
| 710 | 2 | a Karolinska Institutetb Institutionen för medicin, avdelningen för molekylär och klinisk medicin4 org |
| 773 | 0 | t Journal of Internal Medicined : Wileyg 287:1, s. 66-77q 287:1<66-77x 0954-6820x 1365-2796 |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/285373 |
| 856 | 4 8 | u https://doi.org/10.1111/joim.12976 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:141991367 |
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