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Methicillin-suscept...
Methicillin-susceptible staphylococcus aureus endocarditis isolates Are associated with clonal complex 30 genotype and a distinct repertoire of enterotoxins and adhesins
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Nienaber, Juhsien J.C. (author)
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Sharma Kuinkel, Batu K. (author)
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Clarke-Pearson, Michael (author)
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Lamlertthon, Supaporn (author)
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Park, Lawrence (author)
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Rude, Thomas H. (author)
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Barriere, Steve (author)
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Woods, Christopher W. (author)
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Chu, Vivian H. (author)
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Marín, Mercedes (author)
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Bukovski, Suzana (author)
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Garcia, Patricia (author)
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Corey, G. Ralph (author)
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Korman, Tony (author)
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Doco-Lecompte, Thanh (author)
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Murdoch, David R. (author)
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Reller, L. Barth (author)
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Fowler, Vance G. (author)
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- Olaison, Lars, 1949 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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(creator_code:org_t)
- 2011-09-01
- 2011
- English.
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In: Journal of Infectious Diseases. - : Oxford University Press (OUP). - 0022-1899 .- 1537-6613. ; 204, s. 704-713
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Abstract
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- Background. Using multinational collections of methicillin-susceptible Staphylococcus aureus (MSSA) isolates from infective endocarditis (IE) and soft tissue infections (STIs), we sought to (1) validate the finding that S. aureus in clonal complex (CC) 30 is associated with hematogenous complications and (2) test the hypothesis that specific genetic characteristics in S. aureus are associated with infection severity. Methods. IE and STI isolates from 2 cohorts were frequency matched by geographic origin. Isolates underwent spa typing to infer CC and multiplex polymerase chain reaction for presence of virulence genes. Results. 114 isolate pairs were genotyped. IE isolates were more likely to be CC30 (19.5% vs 6.2%; P = .005) and to contain 3 adhesins (clfB, cna, map/eap; P <.0001 for all) and 5 enterotoxins (tst, sea, sed, see, and sei; P ≤.005 for all). CC30 isolates were more likely to contain cna, tst, sea, see, seg, and chp (P < .05 for all). Conclusions. MSSA IE isolates were significantly more likely to be CC30 and to possess a distinct repertoire of virulence genes than MSSA STI isolates from the same region. The genetic basis of this association requires further study. © The Author 2011.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
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Nienaber, Juhsie ...
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Sharma Kuinkel, ...
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Clarke-Pearson, ...
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Lamlertthon, Sup ...
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Park, Lawrence
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Rude, Thomas H.
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show more...
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Barriere, Steve
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Woods, Christoph ...
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Chu, Vivian H.
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Marín, Mercedes
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Bukovski, Suzana
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Garcia, Patricia
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Corey, G. Ralph
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Korman, Tony
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Doco-Lecompte, T ...
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Murdoch, David R ...
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Reller, L. Barth
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Fowler, Vance G.
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Olaison, Lars, 1 ...
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Journal of Infec ...
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University of Gothenburg