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miR-486 is modulate...
miR-486 is modulated by stretch and increases ventricular growth
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- Lange, Stephan (author)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory
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Banerjee, I. (author)
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Carrion, K. (author)
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Serrano, R. (author)
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Habich, L. (author)
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Kameny, R. (author)
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Lengenfelder, L. (author)
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Dalton, N. (author)
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Meili, R. (author)
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- Börgeson, Emma (author)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory
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Peterson, K. (author)
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Ricci, M. (author)
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Lincoln, J. (author)
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Ghassemian, M. (author)
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Fineman, J. (author)
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del Alamo, J. C. (author)
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Nigam, V. (author)
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(creator_code:org_t)
- 2019-09-12
- 2019
- English.
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In: Jci Insight. - : American Society for Clinical Investigation. - 2379-3708. ; 4:19
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http://insight.jci.o...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Perturbations in biomechanical stimuli during cardiac development contribute to congenital cardiac defects such as hypoplastic left heart syndrome (HLHS). This study sought to identify stretch-responsive pathways involved in cardiac development. miRNA-Seq identified miR-486 as being increased in cardiomyocytes exposed to cyclic stretch in vitro. The right ventricles (RVs) of patients with HLHS experienced increased stretch and had a trend toward higher miR-486 levels. Sheep RVs dilated from excessive pulmonary blood flow had 60% more miR-486 compared with control RVs. The left ventricles of newborn mice treated with miR-486 mimic were 16.9%-24.6% larger and displayed a 2.48-fold increase in cardiomyocyte proliferation. miR-486 treatment decreased Fox01 and Smad signaling while increasing the protein levels of Stat1. Stat1 associated with Gata-4 and serum response factor (Srf), 2 key cardiac transcription factors with protein levels that increase in response to miR-486. This is the first report to our knowledge of a stretch-responsive miRNA that increases the growth of the ventricle in vivo.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- congenital heart-disease
- serum response factor
- mechanical stretch
- transcription factor
- cardiac-hypertrophy
- gene-expression
- aortic-valve
- proliferation
- inhibition
- micrornas
- Research & Experimental Medicine
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Lange, Stephan
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Banerjee, I.
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Carrion, K.
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Serrano, R.
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Habich, L.
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Kameny, R.
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show more...
-
Lengenfelder, L.
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Dalton, N.
-
Meili, R.
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Börgeson, Emma
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Peterson, K.
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Ricci, M.
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Lincoln, J.
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Ghassemian, M.
-
Fineman, J.
-
del Alamo, J. C.
-
Nigam, V.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Jci Insight
- By the university
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University of Gothenburg