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Enhancement of ther...
Enhancement of therapeutic potential of mesenchymal stem cell-derived extracellular vesicles
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- Park, Kyong-Su (author)
- Gothenburg University,Göteborgs universitet,Krefting Research Centre
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- Bandeira, Elga (author)
- Gothenburg University,Göteborgs universitet,Krefting Research Centre
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- Shelke, Ganesh V, 1986 (author)
- Gothenburg University,Göteborgs universitet,Krefting Research Centre
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- Lässer, Cecilia, 1981 (author)
- Gothenburg University,Göteborgs universitet,Krefting Research Centre,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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- Lötvall, Jan, 1956 (author)
- Gothenburg University,Göteborgs universitet,Krefting Research Centre
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(creator_code:org_t)
- 2019-09-23
- 2019
- English.
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In: Stem Cell Research & Therapy. - : Springer Science and Business Media LLC. - 1757-6512. ; 10:1
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Abstract
Subject headings
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- After the initial investigations into applications of mesenchymal stem cells (MSCs) for cell therapy, there was increased interest in their secreted soluble factors. Following studies of MSCs and their secreted factors, extracellular vesicles (EVs) released from MSCs have emerged as a new mode of intercellular crosstalk. MSC-derived EVs have been identified as essential signaling mediators under both physiological and pathological conditions, and they appear to be responsible for many of the therapeutic effects of MSCs. In several in vitro and in vivo models, EVs have been observed to have supportive functions in modulating the immune system, mainly mediated by EV-associated proteins and nucleic acids. Moreover, stimulation of MSCs with biophysical or biochemical cues, including EVs from other cells, has been shown to influence the contents and biological activities of subsequent MSC-derived EVs. This review provides on overview of the contents of MSC-derived EVs in terms of their supportive effects, and it provides different perspectives on the manipulation of MSCs to improve the secretion of EVs and subsequent EV-mediated activities. In this review, we discuss the possibilities for manipulating MSCs for EV-based cell therapy and for using EVs to affect the expression of elements of interest in MSCs. In this way, we provide a clear perspective on the state of the art of EVs in cell therapy focusing on MSCs, and we raise pertinent questions and suggestions for knowledge gaps to be filled.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- Extracellular vesicles
- Exosomes
- Mesenchymal stem cells
- Immune regulation
- Therapeutics
- exosome-mimetic nanovesicles
- acute lung injury
- stromal cells
- cancer-cells
- in-vitro
- targeted delivery
- conditioned media
- hypoxia-ischemia
- microvesicles
- angiogenesis
- Cell Biology
Publication and Content Type
- ref (subject category)
- art (subject category)
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