Search: onr:"swepub:oai:gup.ub.gu.se/286480" >
Antifouling activit...
Antifouling activity of portimine, select semisynthetic analogues, and other microalga-derived spirocyclic imines
-
- Brooke, Darby G. (author)
- Cawthron Institute, New Zealand
-
- Cervin, Gunnar, 1967 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för marina vetenskaper,Department of marine sciences,University of Gothenburg, Sweden
-
- Champeau, Olivier (author)
- Cawthron Institute, New Zealand
-
show more...
-
- Harwood, D. Tim (author)
- Cawthron Institute, New Zealand
-
- Pavia, Henrik, 1964 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för marina vetenskaper,Department of marine sciences,University of Gothenburg, Sweden
-
- Selwood, Andrew I. (author)
- Cawthron Institute, New Zealand
-
- Svenson, Johan (author)
- RISE,Kemi och material
-
- Tremblay, Louis A. (author)
- Cawthron Institute, New Zealand; University of Auckland, New Zealand
-
- Cahill, Patrick L. (author)
- Cawthron Institute, New Zealand
-
show less...
-
(creator_code:org_t)
- 2018-12-12
- 2018
- English.
-
In: Biofouling. - : Informa UK Limited. - 0892-7014 .- 1029-2454. ; 34:8, s. 950-961
- Related links:
-
https://gup.ub.gu.se...
-
show more...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
show less...
Abstract
Subject headings
Close
- © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group. A range of natural products from marine invertebrates, bacteria and fungi have been assessed as leads for nature-inspired antifouling (AF) biocides, but little attention has been paid to microalgal-derived compounds. This study assessed the AF activity of the spirocyclic imine portimine (1), which is produced by the benthic mat-forming dinoflagellate Vulcanodinium rugosum. Portimine displayed potent AF activity in a panel of four macrofouling bioassays (EC 50 0.06–62.5 ng ml −1 ), and this activity was distinct from that of the related compounds gymnodimine-A (2), 13-desmethyl spirolide C (3), and pinnatoxin-F (4). The proposed mechanism of action for portimine is induction of apoptosis, based on the observation that portimine inhibited macrofouling organisms at developmental stages known to involve apoptotic processes. Semisynthetic modification of select portions of the portimine molecule was subsequently undertaken. Observed changes in bioactivity of the resulting semisynthetic analogues of portimine were consistent with portimine’s unprecedented 5-membered imine ring structure playing a central role in its AF activity.
Subject headings
- NATURVETENSKAP -- Biologi -- Ekologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Ecology (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Kemiteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Chemical Engineering (hsv//eng)
Keyword
- Bioassay
- biofouling
- microalgae
- natural product
- portimine
- Bioassay
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
-
Biofouling
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
-
Brooke, Darby G.
-
Cervin, Gunnar, ...
-
Champeau, Olivie ...
-
Harwood, D. Tim
-
Pavia, Henrik, 1 ...
-
Selwood, Andrew ...
-
show more...
-
Svenson, Johan
-
Tremblay, Louis ...
-
Cahill, Patrick ...
-
show less...
- About the subject
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Biological Scien ...
-
and Ecology
-
- ENGINEERING AND TECHNOLOGY
-
ENGINEERING AND ...
-
and Chemical Enginee ...
- Articles in the publication
-
Biofouling
- By the university
-
University of Gothenburg
-
RISE