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The association of ...
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Cluver, C. A.Stellenbosch Univ, Dept Obstet & Gynaecol, Francie van Zyl Dr, ZA-7505 Cape Town, South Africa;Mercy Hosp Women, Mercy Perinatal, Melbourne, Vic, Australia; Univ Melbourne, Translat Obstet Grp, Melbourne, Vic, Australia
(author)
The association of prenatal alcohol exposure on the cognitive abilities and behaviour profiles of 4-year-old children: a prospective cohort study
- Article/chapterEnglish2019
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LIBRIS-ID:oai:gup.ub.gu.se/286737
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https://gup.ub.gu.se/publication/286737URI
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https://doi.org/10.1111/1471-0528.15947DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-397643URI
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ObjectiveTo examine the association of prenatal alcohol exposure (PAE) on cognitive abilities and behaviour profiles of 4-year-old children. DesignProspective cohort study. SettingCape Town, South Africa. PopulationA cohort of 500 children. MethodsChildren from the Safe Passage Study, which prospectively collected PAE, were included. Cognition and behavioural profiles were assessed. Children with and without PAE were compared. Mean scores were compared, with P <= 0.05 considered significant. Results were adjusted for confounding factors. Main outcome measuresThe Kaufman Assessment Battery for children measured intellectual and mental ability; the NEPSY-II instrument assessed neurocognitive performance. The caregiver completed the Preschool Child Behaviour checklist to rate the child's problem behaviours and competencies. ResultsTwo hundred children had no PAE, 117 children had mild to moderate PAE (with no binge episodes), 113 children had heavy PAE (with one or two binge episodes), and 70 children had very heavy PAE (with three or more binge episodes). Women who binge drank had significantly higher rates of smoking, marijuana use, and methamphetamine use. Low to moderate PAE had no effect on cognitive ability and behaviour. Very heavy PAE was associated with problems performing simultaneous as well as sequential functions, lower scores in the language and sensorimotor domain, and more attention and pervasive developmental problems. ConclusionsLow to moderate PAE was not associated with cognitive processing or developmental problems. Women who had many binge drinking episodes during pregnancy were the most at risk for cognitive processing, neurocognitive, and behaviour problems in their children at 4 years of age. Tweetable abstractLow to moderate prenatal alcohol use was not associated with cognitive or behavioural problems in 4-year-olds. Tweetable abstract Low to moderate prenatal alcohol use was not associated with cognitive or behavioural problems in 4-year-olds.
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Charles, W.Stellenbosch Univ, Dept Obstet & Gynaecol, Cape Town, South Africa
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van der Merwe, C.Stellenbosch Univ, Dept Psychiat, Cape Town, South Africa; Tygerberg Hosp, Cape Town, South Africa
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Bezuidenhout, H.Tygerberg Hosp, Cape Town, South Africa; Stellenbosch Univ, Dept Biomed Sci, Div Mol Biol & Human Genet, Cape Town, South Africa
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Nel, D.Stellenbosch Univ, Ctr Stat Consultat, Stellenbosch, South Africa
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Groenewald, C.Stellenbosch Univ, Dept Obstet & Gynaecol, Cape Town, South Africa
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Hesselman, Susanne,1973-Uppsala universitet,Klinisk obstetrik,Centrum för klinisk forskning Dalarna(Swepub:uu)sushe649
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Bergman, Lina,1982Uppsala universitet,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology,Centrum för klinisk forskning Dalarna,Klinisk obstetrik,Stellenbosch Univ, Dept Obstet & Gynaecol, Cape Town, South Africa; Univ Gothenburg, Sahlgrenska Acad, Inst Clin Sci, Dept Obstet & Gynaecol, Gothenburg, Sweden(Swepub:uu)linbe681
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Odendaal, H.Stellenbosch Univ, Dept Obstet & Gynaecol, Cape Town, South Africa
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Brink, L.Stellenbosch Univ, Dept Obstet & Gynaecol, Cape Town, South Africa
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Stellenbosch Univ, Dept Obstet & Gynaecol, Francie van Zyl Dr, ZA-7505 Cape Town, South Africa;Mercy Hosp Women, Mercy Perinatal, Melbourne, Vic, Australia; Univ Melbourne, Translat Obstet Grp, Melbourne, Vic, AustraliaStellenbosch Univ, Dept Obstet & Gynaecol, Cape Town, South Africa
(creator_code:org_t)
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In:Bjog-an International Journal of Obstetrics and Gynaecology: Wiley126:13, s. 1588-15971470-03281471-0528
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Cluver, C. A.
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Bezuidenhout, H.
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Nel, D.
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Groenewald, C.
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Odendaal, H.
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