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Validation of a cli...
Validation of a clinical-genetics score to predict hemorrhagic transformations after rtPA.
- Article/chapterEnglish2019
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LIBRIS-ID:oai:gup.ub.gu.se/286990
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https://gup.ub.gu.se/publication/286990URI
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https://doi.org/10.1212/WNL.0000000000007997DOI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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To validate the Genot-PA score, a clinical-genetic logistic regression score that stratifies the thrombolytic therapy safety, in a new cohort of patients with stroke.We enrolled 1,482 recombinant tissue plasminogen activator (rtPA)-treated patients with stroke in Spain and Finland from 2003 to 2016. Cohorts were analyzed on the basis of ethnicity and therapy: Spanish patients treated with IV rtPA within 4.5 hours of onset (cohort A and B) or rtPA in combination with mechanical thrombectomy within 6 hours of onset (cohort C) and Finnish participants treated with IV rtPA within 4.5 hours of onset (cohort D). The Genot-PA score was calculated, and hemorrhagic transformation (HT) and parenchymal hematoma (PH) risks were determined for each score stratum.Genot-PA score was tested in 1,324 (cohort A, n = 726; B, n = 334; C, n = 54; and D, n = 210) patients who had enough information to complete the score. Of these, 213 (16.1%) participants developed HT and 85 (6.4%) developed PH. In cohorts A, B, and D, HT occurrence was predicted by the score (p = 2.02 × 10-6, p = 0.023, p = 0.033); PH prediction was associated in cohorts A through C (p = 0.012, p = 0.034, p = 5.32 × 10-4). Increased frequency of PH events from the lowest to the highest risk group was found (cohort A 4%-15.7%, cohort B 1.5%-18.2%, cohort C 0%-100%). The best odds ratio for PH prediction in the highest-risk group was obtained in cohort A (odds ratio 5.16, 95% confidence interval 1.46-18.08, p = 0.009).The Genot-PA score predicts HT in patients with stroke treated with IV rtPA. Moreover, in an exploratory study, the score was associated with PH risk in mechanical thrombectomy-treated patients.
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Cullell, Natalia
(author)
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Torres-Águila, Nuria
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Muiño, Elena
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Bustamante, Alejandro
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Dávalos, Antonio
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López-Cancio, Elena
(author)
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Ribó, Marc
(author)
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Molina, Carlos A
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Giralt-Steinhauer, Eva
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Soriano-Tárraga, Carolina
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Mola-Caminal, Marina
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Jiménez-Conde, Jordi
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Roquer, Jaume
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Vives-Bauza, Cristófol
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Navarro, Rosa Díaz
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Obach, Victor
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Arenillas, Juan Francisco
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Segura, Tomás
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Serrano-Heras, Gemma
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Martí-Fàbregas, Joan
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Freijo, Marimar
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Cabezas, Juan Antonio
(author)
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Tatlisumak, TurgutGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience(Swepub:gu)xtatlt
(author)
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Heitsch, Laura
(author)
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Ibañez, Laura
(author)
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Cruchaga, Carlos
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Lee, Jin-Moo
(author)
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Strbian, Daniel
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Montaner, Joan
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Fernández-Cadenas, Israel
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Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap
(creator_code:org_t)
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In:Neurology93:91526-632X
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Carrera, Caty
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Cullell, Natalia
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Torres-Águila, N ...
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Muiño, Elena
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Bustamante, Alej ...
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Dávalos, Antonio
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López-Cancio, El ...
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Ribó, Marc
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Molina, Carlos A
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Giralt-Steinhaue ...
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Soriano-Tárraga, ...
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Mola-Caminal, Ma ...
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Jiménez-Conde, J ...
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Roquer, Jaume
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Vives-Bauza, Cri ...
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Navarro, Rosa Dí ...
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Obach, Victor
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Arenillas, Juan ...
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Segura, Tomás
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Serrano-Heras, G ...
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Martí-Fàbregas, ...
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Freijo, Marimar
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Cabezas, Juan An ...
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Tatlisumak, Turg ...
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Heitsch, Laura
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Ibañez, Laura
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Cruchaga, Carlos
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Lee, Jin-Moo
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Strbian, Daniel
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Montaner, Joan
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Fernández-Cadena ...
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Neurology
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