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- Nilsson, Avlant,1985Chalmers tekniska högskola,Chalmers University of Technology,Chalmers University of Technology, Gothenburg, Sweden (author)
Complex I is bypassed during high intensity exercise
- Article/chapterEnglish2019
Publisher, publication year, extent ...
- 2019-11-07
- Springer Science and Business Media LLC,2019
Numbers
- LIBRIS-ID:oai:gup.ub.gu.se/287089
- https://gup.ub.gu.se/publication/287089URI
- https://doi.org/10.1038/s41467-019-12934-8DOI
- https://research.chalmers.se/publication/513809URI
- https://urn.kb.se/resolve?urn=urn:nbn:se:gih:diva-5909URI
Supplementary language notes
- Language:English
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- SwePubSwePub
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Notes
- Human muscles are tailored towards ATP synthesis. When exercising at high work rates muscles convert glucose to lactate, which is less nutrient efficient than respiration. There is hence a trade-off between endurance and power. Metabolic models have been developed to study how limited catalytic capacity of enzymes affects ATP synthesis. Here we integrate an enzyme-constrained metabolic model with proteomics data from muscle fibers. We find that ATP synthesis is constrained by several enzymes. A metabolic bypass of mitochondrial complex I is found to increase the ATP synthesis rate per gram of protein compared to full respiration. To test if this metabolic mode occurs in vivo, we conduct a high resolved incremental exercise tests for five subjects. Their gas exchange at different work rates is accurately reproduced by a whole-body metabolic model incorporating complex I bypass. The study therefore shows how proteome allocation influences metabolism during high intensity exercise.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap hsv//swe
- MEDICAL AND HEALTH SCIENCES Health Sciences hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Farmaceutiska vetenskaper hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Pharmaceutical Sciences hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Idrottsvetenskap hsv//swe
- MEDICAL AND HEALTH SCIENCES Health Sciences Sport and Fitness Sciences hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Fysiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Physiology hsv//eng
- human skeletal-muscle
- lactate metabolism
- efficiency
- atp
- carbohydrate
- performance
- rates
- Medicin/Teknik
Added entries (persons, corporate bodies, meetings, titles ...)
- Björnson, Elias,1988Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberglaboratoriet,Institute of Medicine, Department of Molecular and Clinical Medicine,Wallenberg Laboratory,Chalmers tekniska högskola,Chalmers University of Technology,Chalmers University of Technology, Gothenburg, Sweden(Swepub:cth)eliasb (author)
- Flockhart, MikaelGymnastik- och idrottshögskolan,Åstrandlaboratoriet(Swepub:gih)mikaelf (author)
- Larsen, Filip J,1977-Gymnastik- och idrottshögskolan,Forskningsgruppen Mitokondriell funktion och metabol kontroll(Swepub:gih)filipl (author)
- Nielsen, Jens B,1962Danmarks Tekniske Universitet,Technical University of Denmark,Chalmers tekniska högskola,Chalmers University of Technology,Novo Nordisk Fonden,Novo Nordisk Foundation,Chalmers University of Technology, Gothenburg, Sweden(Swepub:cth)nielsenj (author)
- Chalmers tekniska högskolaChalmers University of Technology, Gothenburg, Sweden (creator_code:org_t)
Related titles
- In:Nature Communications: Springer Science and Business Media LLC102041-1723
Internet link
- https://www.nature.com/articles/s41467-019-12934-8.pdf
- https://research.chalmers.se/publication/513809/file/513809_Fulltext.pdfFULLTEXT
- https://doi.org/10.1038/s41467-019-12934-8Fulltext
- https://gih.diva-portal.org/smash/get/diva2:1369179/FULLTEXT01.pdffulltext:print
- https://gup.ub.gu.se/publication/287089
- https://doi.org/10.1038/s41467-019-12934-8
- https://research.chalmers.se/publication/513809
- https://urn.kb.se/resolve?urn=urn:nbn:se:gih:diva-5909
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