Search: onr:"swepub:oai:gup.ub.gu.se/287270" >
Biomarker-guided cl...
Biomarker-guided clustering of Alzheimer's disease clinical syndromes.
-
Toschi, Nicola (author)
-
Lista, Simone (author)
-
Baldacci, Filippo (author)
-
show more...
-
Cavedo, Enrica (author)
-
- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
-
- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
-
Kilimann, Ingo (author)
-
Teipel, Stefan J (author)
-
Melo Dos Santos, Antonio (author)
-
Epelbaum, Stéphane (author)
-
Lamari, Foudil (author)
-
Genthon, Remy (author)
-
Habert, Marie-Odile (author)
-
Dubois, Bruno (author)
-
Floris, Roberto (author)
-
Garaci, Francesco (author)
-
Vergallo, Andrea (author)
-
Hampel, Harald (author)
-
show less...
-
(creator_code:org_t)
- Elsevier BV, 2019
- 2019
- English.
-
In: Neurobiology of aging. - : Elsevier BV. - 1558-1497 .- 0197-4580. ; 83, s. 42-53
- Related links:
-
https://doi.org/10.1...
-
show more...
-
https://gup.ub.gu.se...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Alzheimer's disease (AD) neuropathology is extremely heterogeneous, and the evolution from preclinical to mild cognitive impairment until dementia is driven by interacting genetic/biological mechanisms not fully captured by current clinical/research criteria. We characterized the heterogeneous "construct" of AD through a cerebrospinal fluid biomarker-guided stratification approach. We analyzed 5 validated pathophysiological cerebrospinal fluid biomarkers (Aβ1-42, t-tau, p-tau181, NFL, YKL-40) in 113 participants (healthy controls [N= 20], subjective memory complainers [N= 36], mild cognitive impairment [N= 20], and AD dementia [N= 37], age: 66.7 ± 10.4, 70.4 ± 7.7, 71.7 ± 8.4, 76.2 ± 3.5years [mean ± SD], respectively) using Density-Based Spatial Clustering of Applications with Noise, which does not require a priori determination of the number of clusters. We found 5 distinct clusters (sizes: N= 38, 16, 24, 14, and 21) whose composition was independent of phenotypical groups. Two clusters showed biomarker profiles linked to neurodegenerative processes not associated with classical AD-related pathophysiology. One cluster was characterized by the neuroinflammation biomarker YKL-40. Combining nonlinear data aggregation with informative biomarkers can generate novel patient strata which are representative of cellular/molecular pathophysiology and may aid in predicting disease evolution and mechanistic drug response.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Toschi, Nicola
-
Lista, Simone
-
Baldacci, Filipp ...
-
Cavedo, Enrica
-
Zetterberg, Henr ...
-
Blennow, Kaj, 19 ...
-
show more...
-
Kilimann, Ingo
-
Teipel, Stefan J
-
Melo Dos Santos, ...
-
Epelbaum, Stépha ...
-
Lamari, Foudil
-
Genthon, Remy
-
Habert, Marie-Od ...
-
Dubois, Bruno
-
Floris, Roberto
-
Garaci, Francesc ...
-
Vergallo, Andrea
-
Hampel, Harald
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Neurosciences
- Articles in the publication
-
Neurobiology of ...
- By the university
-
University of Gothenburg