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Microbial changes i...
Microbial changes in relation to oral mucositis in autologous hematopoietic stem cell transplantation recipients
- Article/chapterEnglish2019
Publisher, publication year, extent ...
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2019-11-15
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Springer Science and Business Media LLC,2019
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/287610
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https://gup.ub.gu.se/publication/287610URI
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https://doi.org/10.1038/s41598-019-53073-wDOI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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The aim of this prospective, two center study was to investigate the dynamics of the microbial changes in relation to the development of ulcerative oral mucositis in autologous SCT (autoSCT) recipients. Fifty-one patients were diagnosed with multiple myeloma and treated with high-dose melphalan followed by autoSCT. They were evaluated before, three times weekly during hospitalization, and three months after autoSCT. At each time point an oral rinse was collected and the presence or absence of ulcerative oral mucositis (UOM) was scored (WHO scale). Oral microbiome was determined by using 16S rRNA amplicon sequencing and fungal load by qPCR. Twenty patients (39%) developed UOM. The oral microbiome changed significantly after autoSCT and returned to pre-autoSCT composition after three months. However, changes in microbial diversity and similarity were more pronounced and rapid in patients who developed UOM compared to patients who did not. Already before autoSCT, different taxa discriminated between the 2 groups, suggesting microbially-driven risk factors. Samples with high fungal load (>0.1%) had a significantly different microbial profile from samples without fungi. In conclusion, autoSCT induced significant and reversible changes in the oral microbiome, while patients who did not develop ulcerative oral mucositis had a more resilient microbial ecosystem.
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Raber-Durlacher, J. E.
(author)
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Koppelmans, R. G. A.
(author)
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Huysmans, Mcdnjm
(author)
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Potting, C.
(author)
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van Leeuwen, S. J. M.
(author)
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Hazenberg, M. D.
(author)
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Brennan, M. T.
(author)
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von Bültzingslöwen, Inger,1947Gothenburg University,Göteborgs universitet,Institutionen för odontologi,Institute of Odontology(Swepub:gu)xvonin
(author)
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Johansson, J. E.
(author)
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de Soet, J. J.
(author)
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Haverman, T. M.
(author)
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Buijs, M. J.
(author)
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Brandt, B. W.
(author)
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Rozema, F. R.
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Blijlevens, N. M. A.
(author)
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Zaura, E.
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Göteborgs universitetInstitutionen för odontologi
(creator_code:org_t)
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In:Scientific Reports: Springer Science and Business Media LLC92045-2322
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Laheij, Amga
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Raber-Durlacher, ...
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Koppelmans, R. G ...
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Huysmans, Mcdnjm
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Potting, C.
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van Leeuwen, S. ...
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Hazenberg, M. D.
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Brennan, M. T.
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von Bültzingslöw ...
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Johansson, J. E.
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de Soet, J. J.
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Haverman, T. M.
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Buijs, M. J.
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Brandt, B. W.
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Rozema, F. R.
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Blijlevens, N. M ...
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Zaura, E.
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- MEDICAL AND HEALTH SCIENCES
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and Dentistry
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University of Gothenburg