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Global monitoring o...
Global monitoring of antimicrobial resistance based on metagenomics analyses of urban sewage
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Hendriksen, Rene S. (author)
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Munk, Patrick (author)
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Njage, Patrick (author)
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van Bunnik, Bram (author)
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McNally, Luke (author)
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Lukjancenko, Oksana (author)
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Röder, Timo (author)
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Nieuwenhuijse, David (author)
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Pedersen, Susanne Karlsmose (author)
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Kjeldgaard, Jette (author)
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Kaas, Rolf S. (author)
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Clausen, Philip Thomas Lanken Conradsen (author)
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Vogt, Josef Korbinian (author)
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Leekitcharoenphon, Pimlapas (author)
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van de Schans, Milou G.M. (author)
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Zuidema, Tina (author)
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de Roda Husman, Ana Maria (author)
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Rasmussen, Simon (author)
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Petersen, Bent (author)
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Bego, Artan (author)
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Rees, Catherine (author)
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Cassar, Susan (author)
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Coventry, Kris (author)
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Collignon, Peter (author)
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Allerberger, Franz (author)
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Rahube, Teddie O. (author)
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Oliveira, Guilherme (author)
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Ivanov, Ivan (author)
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Vuthy, Yith (author)
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Sopheak, Thet (author)
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Yost, Christopher K. (author)
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Ke, Changwen (author)
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Zheng, Huanying (author)
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Baisheng, Li (author)
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Jiao, Xiaoyang (author)
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Donado-Godoy, Pilar (author)
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Coulibaly, Kalpy Julien (author)
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Jergović, Matijana (author)
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Hrenovic, Jasna (author)
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Karpíšková, Renáta (author)
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Villacis, Jose Eduardo (author)
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Legesse, Mengistu (author)
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Eguale, Tadesse (author)
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Heikinheimo, Annamari (author)
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Malania, Lile (author)
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Nitsche, Andreas (author)
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Brinkmann, Annika (author)
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Saba, Courage Kosi Setsoafia (author)
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Kocsis, Bela (author)
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Solymosi, Norbert (author)
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Thorsteinsdottir, Thorunn R. (author)
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Hatha, Abdulla Mohamed (author)
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Alebouyeh, Masoud (author)
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Morris, Dearbhaile (author)
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Cormican, Martin (author)
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O’Connor, Louise (author)
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Moran-Gilad, Jacob (author)
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Alba, Patricia (author)
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Battisti, Antonio (author)
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Shakenova, Zeinegul (author)
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Kiiyukia, Ciira (author)
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Ng’eno, Eric (author)
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Raka, Lul (author)
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Avsejenko, Jeļena (author)
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Bērziņš, Aivars (author)
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Bartkevics, Vadims (author)
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Penny, Christian (author)
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Rajandas, Heraa (author)
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Surveillance project consortium#, The Global Sewage Surveillance project consortium# (author)
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Parimannan, Sivachandran (author)
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Haber, Malcolm Vella (author)
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Pal, Pushkar (author)
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Jeunen, Gert Jan (author)
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Gemmell, Neil (author)
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Fashae, Kayode (author)
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Holmstad, Rune (author)
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Hasan, Rumina (author)
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Shakoor, Sadia (author)
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Rojas, Maria Luz Zamudio (author)
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Wasyl, Dariusz (author)
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Bosevska, Golubinka (author)
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Kochubovski, Mihail (author)
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Radu, Cojocaru (author)
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Gassama, Amy (author)
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Radosavljevic, Vladimir (author)
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Wuertz, Stefan (author)
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Zuniga-Montanez, Rogelio (author)
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Tay, Moon Y.F. (author)
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- Larsson, D. G. Joakim, 1969 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,CARe - Centrum för antibiotikaresistensforskning,Institute of Biomedicine,Centre for antibiotic resistance research, CARe
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Pastuchova, Katarina (author)
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Truska, Peter (author)
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Trkov, Marija (author)
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Esterhuyse, Kerneels (author)
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Keddy, Karen (author)
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Cerdà-Cuéllar, Marta (author)
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Pathirage, Sujatha (author)
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- Norrgren, Leif (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Inst för biomedicin och veterinär folkhälsovetenskap,Department of Biomedical Science and Veterinary Public Health
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- Örn, Stefan (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Inst för biomedicin och veterinär folkhälsovetenskap,Department of Biomedical Science and Veterinary Public Health
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Heijden, Tanja Van der (author)
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Kumburu, Happiness Houka (author)
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- Larsson, D. G. Joakim, 1969 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,CARe - Centrum för antibiotikaresistensforskning,Institute of Biomedicine,Centre for antibiotic resistance research, CARe
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(creator_code:org_t)
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- 2019-03-08
- 2019
- English.
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In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1
- Related links:
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https://www.nature.c...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://res.slu.se/i...
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Abstract
Subject headings
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- © 2019, The Author(s). Antimicrobial resistance (AMR) is a serious threat to global public health, but obtaining representative data on AMR for healthy human populations is difficult. Here, we use metagenomic analysis of untreated sewage to characterize the bacterial resistome from 79 sites in 60 countries. We find systematic differences in abundance and diversity of AMR genes between Europe/North-America/Oceania and Africa/Asia/South-America. Antimicrobial use data and bacterial taxonomy only explains a minor part of the AMR variation that we observe. We find no evidence for cross-selection between antimicrobial classes, or for effect of air travel between sites. However, AMR gene abundance strongly correlates with socio-economic, health and environmental factors, which we use to predict AMR gene abundances in all countries in the world. Our findings suggest that global AMR gene diversity and abundance vary by region, and that improving sanitation and health could potentially limit the global burden of AMR. We propose metagenomic analysis of sewage as an ethically acceptable and economically feasible approach for continuous global surveillance and prediction of AMR.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Hendriksen, Rene ...
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Munk, Patrick
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Njage, Patrick
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van Bunnik, Bram
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McNally, Luke
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Lukjancenko, Oks ...
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show more...
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Röder, Timo
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Nieuwenhuijse, D ...
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Pedersen, Susann ...
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Kjeldgaard, Jett ...
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Kaas, Rolf S.
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Clausen, Philip ...
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Vogt, Josef Korb ...
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Leekitcharoenpho ...
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van de Schans, M ...
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Zuidema, Tina
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de Roda Husman, ...
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Rasmussen, Simon
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Petersen, Bent
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Bego, Artan
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Rees, Catherine
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Cassar, Susan
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Coventry, Kris
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Collignon, Peter
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Allerberger, Fra ...
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Rahube, Teddie O ...
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Oliveira, Guilhe ...
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Ivanov, Ivan
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Vuthy, Yith
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Sopheak, Thet
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Yost, Christophe ...
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Ke, Changwen
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Zheng, Huanying
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Baisheng, Li
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Jiao, Xiaoyang
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Donado-Godoy, Pi ...
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Coulibaly, Kalpy ...
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Jergović, Matija ...
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Hrenovic, Jasna
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Karpíšková, Rená ...
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Villacis, Jose E ...
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Legesse, Mengist ...
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Eguale, Tadesse
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Heikinheimo, Ann ...
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Malania, Lile
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Nitsche, Andreas
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Brinkmann, Annik ...
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Saba, Courage Ko ...
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Kocsis, Bela
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Solymosi, Norber ...
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Thorsteinsdottir ...
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Hatha, Abdulla M ...
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Alebouyeh, Masou ...
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Morris, Dearbhai ...
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Cormican, Martin
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O’Connor, Louise
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Moran-Gilad, Jac ...
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Alba, Patricia
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Battisti, Antoni ...
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Shakenova, Zeine ...
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Kiiyukia, Ciira
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Ng’eno, Eric
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Raka, Lul
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Avsejenko, Jeļen ...
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Bērziņš, Aivars
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Bartkevics, Vadi ...
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Penny, Christian
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Rajandas, Heraa
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Surveillance pro ...
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Parimannan, Siva ...
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Haber, Malcolm V ...
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Pal, Pushkar
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Jeunen, Gert Jan
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Gemmell, Neil
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Fashae, Kayode
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Holmstad, Rune
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Hasan, Rumina
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Shakoor, Sadia
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Rojas, Maria Luz ...
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Wasyl, Dariusz
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Bosevska, Golubi ...
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Kochubovski, Mih ...
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Radu, Cojocaru
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Gassama, Amy
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Radosavljevic, V ...
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Wuertz, Stefan
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Zuniga-Montanez, ...
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Tay, Moon Y.F.
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Larsson, D. G. J ...
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Pastuchova, Kata ...
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Truska, Peter
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Trkov, Marija
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Esterhuyse, Kern ...
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Keddy, Karen
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Cerdà-Cuéllar, M ...
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Pathirage, Sujat ...
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Norrgren, Leif
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Örn, Stefan
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Heijden, Tanja V ...
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Kumburu, Happine ...
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
- Articles in the publication
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Nature Communica ...
- By the university
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University of Gothenburg
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Swedish University of Agricultural Sciences