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Neural correlates o...
Neural correlates of the DMT experience assessed with multivariate EEG
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Timmermann, C. (author)
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Roseman, L. (author)
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Schartner, M. (author)
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Milliere, R. (author)
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Williams, L. T. J. (author)
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Erritzoe, D. (author)
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Muthukumaraswamy, S. (author)
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- Ashton, Michael, 1955 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Neuroscience and Physiology, Department of Pharmacology
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- Bendrioua, Adam (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Neuroscience and Physiology, Department of Pharmacology
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Kaur, O. (author)
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Turton, S. (author)
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Nour, M. M. (author)
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Day, C. M. (author)
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Leech, R. (author)
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Nutt, D. J. (author)
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Carhart-Harris, R. L. (author)
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(creator_code:org_t)
- 2019-11-19
- 2019
- English.
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In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 9
- Related links:
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https://www.nature.c...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Studying transitions in and out of the altered state of consciousness caused by intravenous (IV) N,N-Dimethyltryptamine (DMT - a fast-acting tryptamine psychedelic) offers a safe and powerful means of advancing knowledge on the neurobiology of conscious states. Here we sought to investigate the effects of IV DMT on the power spectrum and signal diversity of human brain activity (6 female, 7 male) recorded via multivariate EEG, and plot relationships between subjective experience, brain activity and drug plasma concentrations across time. Compared with placebo, DMT markedly reduced oscillatory power in the alpha and beta bands and robustly increased spontaneous signal diversity. Time-referenced and neurophenomenological analyses revealed close relationships between changes in various aspects of subjective experience and changes in brain activity. Importantly, the emergence of oscillatory activity within the delta and theta frequency bands was found to correlate with the peak of the experience - particularly its eyes-closed visual component. These findings highlight marked changes in oscillatory activity and signal diversity with DMT that parallel broad and specific components of the subjective experience, thus advancing our understanding of the neurobiological underpinnings of immersive states of consciousness.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- alpha oscillations
- dose-response
- n
- n-dimethyltryptamine
- underlies
- ayahuasca
- humans
- states
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Timmermann, C.
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Roseman, L.
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Schartner, M.
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Milliere, R.
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Williams, L. T. ...
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Erritzoe, D.
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show more...
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Muthukumaraswamy ...
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Ashton, Michael, ...
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Bendrioua, Adam
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Kaur, O.
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Turton, S.
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Nour, M. M.
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Day, C. M.
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Leech, R.
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Nutt, D. J.
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Carhart-Harris, ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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Scientific Repor ...
- By the university
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University of Gothenburg