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CSF and blood bioma...
CSF and blood biomarkers for Parkinson's disease.
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- Parnetti, Lucilla (author)
- University of Perugia
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- Gaetani, Lorenzo (author)
- University of Perugia
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- Eusebi, Paolo (author)
- University of Perugia
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- Paciotti, Silvia (author)
- University of Perugia
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- Hansson, Oskar (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital
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- El-Agnaf, Omar (author)
- Hamad Bin Khalifa University
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- Mollenhauer, Brit (author)
- University Medical Center Göttingen,Paracelsus-Elena-Klinik Kassel
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- Blennow, Kaj, 1958 (author)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Sahlgrenska University Hospital
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- Calabresi, Paolo (author)
- University of Perugia,IRCCS Fondazione Santa Lucia
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(creator_code:org_t)
- 2019
- 2019
- English.
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In: The Lancet. Neurology. - 1474-4465 .- 1474-4422. ; 18:6, s. 573-586
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Abstract
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- In the management of Parkinson's disease, reliable diagnostic and prognostic biomarkers are urgently needed. The diagnosis of Parkinson's disease mostly relies on clinical symptoms, which hampers the detection of the earliest phases of the disease-the time at which treatment with forthcoming disease-modifying drugs could have the greatest therapeutic effect. Reliable prognostic markers could help in predicting the response to treatments. Evidence suggests potential diagnostic and prognostic value of CSF and blood biomarkers closely reflecting the pathophysiology of Parkinson's disease, such as α-synuclein species, lysosomal enzymes, markers of amyloid and tau pathology, and neurofilament light chain. A combination of multiple CSF biomarkers has emerged as an accurate diagnostic and prognostic model. With respect to early diagnosis, the measurement of CSF α-synuclein aggregates is providing encouraging preliminary results. Blood α-synuclein species and neurofilament light chain are also under investigation because they would provide a non-invasive tool, both for early and differential diagnosis of Parkinson's disease versus atypical parkinsonian disorders, and for disease monitoring. In view of adopting CSF and blood biomarkers for improving Parkinson's disease diagnostic and prognostic accuracy, further validation in large independent cohorts is needed.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Parnetti, Lucill ...
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Gaetani, Lorenzo
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Eusebi, Paolo
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Paciotti, Silvia
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Hansson, Oskar
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El-Agnaf, Omar
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show more...
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Mollenhauer, Bri ...
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Blennow, Kaj, 19 ...
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Calabresi, Paolo
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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The Lancet. Neur ...
- By the university
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University of Gothenburg
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Lund University