Analysis of the bone ultrastructure around biodegradable Mg-xGd implants using small angle X-ray scattering and X-ray diffraction

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Zeller-Plumhoff, B.Division of Metallic Biomaterials, Helmholtz Zentrum Geesthacht, Institute for Materials Research, Max-Planck-Straße 1, 21502 Geesthacht, Germany (author)

Analysis of the bone ultrastructure around biodegradable Mg-xGd implants using small angle X-ray scattering and X-ray diffraction

Article/chapterEnglish2020

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Elsevier BV,2020

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LIBRIS-ID:oai:gup.ub.gu.se/289463
https://gup.ub.gu.se/publication/289463URI
https://doi.org/10.1016/j.actbio.2019.11.030DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-6310URI

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Language:English

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Subject category:art swepub-publicationtype

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Magnesium alloys are increasingly researched as temporary biodegradable metal implants in bone applications due to their mechanical properties which are more similar to bone than conventional implant metals and the fact that Magnesium occurs naturally within the body. However, the degradation processes in vivo and in particular the interaction of the bone with the degrading material need to be further investigated. In this study we are presenting the first quantitative comparison of the bone ultrastructure formed at the interface of biodegradable Mg-5Gd and Mg-10Gd implants and titanium and PEEK implants after 4, 8 and 12 weeks healing time using two-dimensional small angle X-ray scattering and X-ray diffraction. Differences in mineralization, orientation and thickness of the hydroxyapatite are assessed. We find statistically significant (p < 0.05) differences for the lattice spacing of the (310)-reflex of hydroxyapatite between titanium and Mg-xGd materials, as well as for the (310) crystal size between titanium and Mg-5Gd, indicating a possible deposition of Mg within the bone matrix. The (310) lattice spacing and crystallite size further differ significantly between implant degradation layer and surrounding bone (p < 0.001 for Mg-10Gd), suggesting apatite formation with significant amounts of Gd and Mg within the degradation layer. Statement of significance Biodegradable Magnesium-based alloys are emerging as a viable alternative for temporary bone implant applications. However, in order to understand if the degradation of the implant material influences the bone ultrastructure, it is necessary to study the bone structure using high-resolution techniques. We have therefore employed 2D small angle X-ray scattering and X-ray diffraction to study the bone ultrastructure surrounding Magnesium-Gadolinium alloys as well as Titanium and PEEK alloys at three different healing times. This is the first time, that the bone ultrastructure around these materials is directly compared and that a statistical evaluation is performed. We found differences indicating a possible deposition of Mg within the bone matrix as well as a local deposition of Mg and/or Gd at the implant site. Data availability statement The raw/processed data required to reproduce these findings cannot be shared at this time as the data also forms part of an ongoing study. (C) 2019 The Authors. Published by Elsevier Ltd on behalf of Acta Materialia Inc.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Odontologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Dentistry hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Medicinsk bioteknologi Biomaterialvetenskap hsv//swe
MEDICAL AND HEALTH SCIENCES Medical Biotechnology Biomaterials Science hsv//eng
Biodegradable magnesium implants
Bone ultrastructure
Bone-implant
interface
in-vitro
magnesium
hydroxyapatite
nanostructure
alloys
crystallites
titanium
Engineering
Materials Science
Biodegradable magnesium implants

Added entries (persons, corporate bodies, meetings, titles ...)

Malich, C.Division of Metallic Biomaterials, Helmholtz Zentrum Geesthacht, Institute for Materials Research, Max-Planck-Straße 1, 21502 Geesthacht, Germany (author)
Kruger, D.Division of Metallic Biomaterials, Helmholtz Zentrum Geesthacht, Institute for Materials Research, Max-Planck-Straße 1, 21502 Geesthacht, Germany (author)
Campbell, G.Division of Metallic Biomaterials, Helmholtz Zentrum Geesthacht, Institute for Materials Research, Max-Planck-Straße 1, 21502 Geesthacht, Germany (author)
Wiese, B.Division of Metallic Biomaterials, Helmholtz Zentrum Geesthacht, Institute for Materials Research, Max-Planck-Straße 1, 21502 Geesthacht, Germany (author)
Galli, SilviaMalmö universitet,Odontologiska fakulteten (OD),Biofilms Research Center for Biointerfaces(Swepub:mau)ac0585 (author)
Wennerberg, Ann,1955Gothenburg University,Göteborgs universitet,Institutionen för odontologi,Institute of Odontology(Swepub:mau)odanwe (author)
Willumeit-Romer, R.Division of Metallic Biomaterials, Helmholtz Zentrum Geesthacht, Institute for Materials Research, Max-Planck-Straße 1, 21502 Geesthacht, Germany (author)
Wieland, D. C. F.Division of Metallic Biomaterials, Helmholtz Zentrum Geesthacht, Institute for Materials Research, Max-Planck-Straße 1, 21502 Geesthacht, Germany (author)
Division of Metallic Biomaterials, Helmholtz Zentrum Geesthacht, Institute for Materials Research, Max-Planck-Straße 1, 21502 Geesthacht, GermanyOdontologiska fakulteten (OD) (creator_code:org_t)

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In:Acta Biomaterialia: Elsevier BV101, s. 637-6451742-70611878-7568

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Dentistry

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Medical Biotechn ...; and Biomaterials Sci ...

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