Search: onr:"swepub:oai:gup.ub.gu.se/289671" >
Being overweight in...
Being overweight in childhood, puberty, or early adulthood: Changing asthma risk in the next generation?
-
- Johannessen, A. (author)
- Univ Bergen, Dept Global Publ Hlth & Primary Care, N-5021 Bergen, Norway;Haukeland Hosp, Dept Occupat Med, Bergen, Norway
-
- Lønnebotn, M. (author)
- Univ Bergen, Dept Global Publ Hlth & Primary Care, N-5021 Bergen, Norway;Haukeland Hosp, Dept Occupat Med, Bergen, Norway
-
- Calciano, L. (author)
- Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy
-
show more...
-
- Benediktsdóttir, B. (author)
- Univ Iceland, Fac Med, Reykjavik, Iceland;Landspitali Univ Hosp, Dept Sleep, Reykjavik, Iceland
-
- Bertelsen, R. J. (author)
- Univ Bergen, Dept Clin Sci, Bergen, Norway,Tartu Univ Hosp, Lung Clin, Tartu, Estonia
-
- Bråbäck, Lennart (author)
- Umeå universitet,Avdelningen för hållbar hälsa,Dept Publ Hlth & Clin Med, Occupat & Environm Med, Umeå, Sweden
-
- Dharmage, S. (author)
- Univ Melbourne, Sch Populat & Global Hlth, Allergy & Lung Hlth Unit, Melbourne, Vic, Australia
-
- Franklin, Karl A (author)
- Umeå universitet,Kirurgi,Umeå Univ, Surg, Dept Surg & Perioperat Sci, Umeå, Sweden
-
- Gislason, T. (author)
- Landspitali Univ Hosp, Dept Sleep, Reykjavik, Iceland
-
- Holm, M. (author)
- Sahlgrens Univ Hosp, Dept Occupat & Environm Med, Gothenburg, Sweden
-
- Janson, Christer (author)
- Uppsala universitet,Lung- allergi- och sömnforskning
-
- Jarvis, D. (author)
- Imperial Coll, Natl Heart & Lung Inst, Fac Med, London, England
-
Jõgi, R. (author)
-
- Kim, Jeong-Lim (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine,Univ Gothenburg, Sahlgrenska Acad, Dept Publ Hlth & Community Med, Occupat & Environm Med, Gothenburg, Sweden
-
- Kirkeleit, J. (author)
- Univ Bergen, Dept Global Publ Hlth & Primary Care, N-5021 Bergen, Norway
-
- Lodge, C. (author)
- Univ Melbourne, Dept Populat Hlth, Melbourne, Vic, Australia
-
- Malinovschi, Andrei, 1978- (author)
- Uppsala universitet,Klinisk fysiologi
-
- Martinez-Moratalla, J. (author)
- CHUA, Serv Neurol, Serv Salud Castilla La Mancha SESCAM, Albacete, Spain
-
- Nilsen, R. M. (author)
- Bergen Univ Coll, Dept Nursing, Bergen, Norway
-
- Pereira-Vega, A. (author)
- Hosp Juan Ramon Jimenez, Pneumol Sect, Huelva, Spain
-
- Real, F. G. (author)
- Univ Bergen, Dept Clin Sci, Bergen, Norway;Haukeland Hosp, Dept Obstet & Gynecol, Bergen, Norway
-
- Schlünssen, V. (author)
- Aarhus Univ, Dept Publ Hlth, Aarhus, Denmark
-
- Accordini, S. (author)
- Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy
-
- Svanes, C. (author)
- Haukeland Hosp, Dept Occupat Med, Bergen, Norway;Univ Bergen, Dept Global Publ Hlth & Primary Care, Ctr Int Hlth, Bergen, Norway
-
show less...
-
(creator_code:org_t)
- Elsevier BV, 2020
- 2020
- English.
-
In: Journal of Allergy and Clinical Immunology. - : Elsevier BV. - 0091-6749 .- 1097-6825. ; 145:3
- Related links:
-
http://www.jacionlin...
-
show more...
-
https://doi.org/10.1...
-
https://umu.diva-por... (primary) (Raw object)
-
https://uu.diva-port... (primary) (Raw object)
-
https://gup.ub.gu.se...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
https://urn.kb.se/re...
-
show less...
Abstract
Subject headings
Close
- Background: Overweight status and asthma have increased during the last decades. Being overweight is a known risk factor for asthma, but it is not known whether it might also increase asthma risk in the next generation. Objective: We aimed to examine whether parents being overweight in childhood, adolescence, or adulthood is associated with asthma in their offspring. Methods: We included 6347 adult offspring (age, 18-52 years) investigated in the Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) multigeneration study of 2044 fathers and 2549 mothers (age, 37-66 years) investigated in the European Community Respiratory Health Survey (ECRHS) study. Associations of parental overweight status at age 8 years, puberty, and age 30 years with offspring's childhood overweight status (potential mediator) and offspring's asthma with or without nasal allergies (outcomes) was analyzed by using 2-level logistic regression and 2-level multinomial logistic regression, respectively. Counterfactual-based mediation analysis was performed to establish whether observed associations were direct or indirect effects mediated through the offspring's own overweight status. Results: We found statistically significant associations between both fathers' and mothers' childhood overweight status and offspring's childhood overweight status (odds ratio, 2.23 [95% CI, 1.45-3.42] and 2.45 [95% CI, 1.86-3.22], respectively). We also found a statistically significant effect of fathers' onset of being overweight in puberty on offspring's asthma without nasal allergies (relative risk ratio, 2.31 [95% CI, 1.23-4.33]). This effect was direct and not mediated through the offspring's own overweight status. No effect on offspring's asthma with nasal allergies was found. Conclusion: Our findings suggest that metabolic factors long before conception can increase asthma risk and that male puberty is a time window of particular importance for offspring's health. © 2019 The Authors
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Keyword
- Ageing Lungs in European Cohorts study
- epidemiology
- multilevel mediation model
- offspring
- parental risk factors
- Ageing Lungs in European Cohorts study
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Johannessen, A.
-
Lønnebotn, M.
-
Calciano, L.
-
Benediktsdóttir, ...
-
Bertelsen, R. J.
-
Bråbäck, Lennart
-
show more...
-
Dharmage, S.
-
Franklin, Karl A
-
Gislason, T.
-
Holm, M.
-
Janson, Christer
-
Jarvis, D.
-
Jõgi, R.
-
Kim, Jeong-Lim
-
Kirkeleit, J.
-
Lodge, C.
-
Malinovschi, And ...
-
Martinez-Moratal ...
-
Nilsen, R. M.
-
Pereira-Vega, A.
-
Real, F. G.
-
Schlünssen, V.
-
Accordini, S.
-
Svanes, C.
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Health Sciences
-
and Public Health Gl ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Immunology in th ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Respiratory Medi ...
- Articles in the publication
-
Journal of Aller ...
- By the university
-
University of Gothenburg
-
Umeå University
-
Uppsala University