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  • Christiansen, Morten KAarhus University Hospital,Aarhus University,Aarhus Univ Hosp, Denmark; Aarhus Univ, Denmark (author)

Incidence, Predictors, and Success of Ventricular Tachycardia Catheter Ablation in Arrhythmogenic Right Ventricular Cardiomyopathy (from the Nordic ARVC Registry).

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • Elsevier BV,2020

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  • LIBRIS-ID:oai:gup.ub.gu.se/289776
  • https://gup.ub.gu.se/publication/289776URI
  • https://doi.org/10.1016/j.amjcard.2019.11.026DOI
  • https://lup.lub.lu.se/record/02d64ea1-a307-4434-a16f-cdf932767601URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-164660URI

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  • Language:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

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  • Catheter ablation may reduce ventricular tachycardia (VT) burden in arrhythmogenic right ventricular cardiomyopathy (ARVC) patients. However, little is known about factors predicting need for ablation. Therefore, we sought to investigate predictors and use of VT ablation and to evaluate the postprocedural outcome in ARVC patients. We studied 435 patients from the Nordic ARVC registry including 220 probands with definite ARVC according to the 2010 task force criteria and 215 mutation-carrying relatives identified through cascade screening. Patients were followed until first-time VT ablation, death, heart transplantation, or January 1st 2018. Additionally, patients undergoing VT ablation were further followed from the time of ablation for recurrent ventricular arrhythmias. The cumulative use of VT ablation was 4% (95% confidence interval [CI] 3% to 6%) and 11% (95% CI 8% to 15%) after 1 and 10 years. All procedures were performed in probands in whom cumulative use was 8% (95% CI 5% to 12%) and 20% (95% CI 15% to 26%). In adjusted analyses among probands, only young age predicted ablation. In patients undergoing ablation, risk of recurrent arrhythmias was 59% (95% CI 44% to 71%) and 74% (95% CI 59% to 84%) 1 and 5 years after the procedure. Despite high recurrence rates, the burden of ventricular arrhythmias was reduced after ablation (p=0.0042). Young age, use of several antiarrhythmic drugs and inducibility to VT after ablation were associated with an unfavorable outcome. In conclusion, twenty percent of ARVC probands developed a clinical indication for VT ablation within 10 years whereas mutation-carrying relatives were without such need. Although the burden of ventricular arrhythmias decreased after ablation, risk of recurrence was substantial.

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  • Haugaa, Kristina HOslo university hospital,Oslo Univ Hosp, Norway (author)
  • Svensson, AnneliLinköpings universitet,Linköping University,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US(Swepub:liu)annsv58 (author)
  • Gilljam, ThomasGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Sahlgrenska University Hospital,Sahlgrens Univ Hosp, Sweden(Swepub:gu)xgillt (author)
  • Madsen, TrineAalborg University Hospital,Aalborg Univ Hosp, Denmark (author)
  • Hansen, JimUniversity of Copenhagen,Univ Copenhagen, Denmark (author)
  • Holst, Anders GCopenhagen University Hospital,University of Copenhagen,Rigshosp, Denmark; Univ Copenhagen, Denmark (author)
  • Bundgaard, HenningUniversity of Copenhagen,Copenhagen University Hospital,Rigshosp, Denmark; Univ Copenhagen, Denmark (author)
  • Edvardsen, ThorOslo university hospital,Oslo Univ Hosp, Norway (author)
  • Svendsen, Jesper HCopenhagen University Hospital,University of Copenhagen,Rigshosp, Denmark; Univ Copenhagen, Denmark (author)
  • Platonov, Pyotr G.Lund University,Lunds universitet,Electrocardiology Research Group - CIEL,Forskargrupper vid Lunds universitet,Lund University Research Groups,Lund Univ, Sweden(Swepub:lu)kard-ppl (author)
  • Jensen, Henrik KAarhus University Hospital,Aarhus University,Aarhus Univ Hosp, Denmark; Aarhus Univ, Denmark (author)
  • Aarhus University HospitalAarhus University (creator_code:org_t)

Related titles

  • In:The American journal of cardiology: Elsevier BV125:5, s. 803-8111879-19130002-9149

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