Search: onr:"swepub:oai:gup.ub.gu.se/289842" > IL-1beta, IL-6, TNF...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 05555naa a2200817 4500 | |
001 | oai:gup.ub.gu.se/289842 | |
003 | SwePub | |
008 | 240528s1998 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/2898422 URI |
024 | 7 | a https://doi.org/10.1034/j.1600-0412.1998.770701.x2 DOI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Mattsby-Baltzer, Inger,d 1949u Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk bakteriologi,Institute of Laboratory Medicine, Dept of Clinical Bacteriology4 aut0 (Swepub:gu)xmatin |
245 | 1 0 | a IL-1beta, IL-6, TNFalpha, fetal fibronectin, and endotoxin in the lower genital tract of pregnant women with bacterial vaginosis. |
264 | c 2003-06-11 | |
264 | 1 | b Wiley,c 1998 |
520 | a In our studies on women with bacterial vaginosis (BV) in early pregnancy a strong association has been found between BV and the levels of endotoxin or interleukin-1alpha (IL-1alpha) in the lower genital tract. In the present study we investigated if an association could be found between BV and other cytokines (IL-1beta, IL-6, tumor necrosis factor alpha, TNF) or fetal fibronectin (FFN). The cytokine-inducing capacity of endotoxins present in the cervical mucus was explored in a monocytic cell assay.Cervical mucus or cervicovaginal fluid was collected from women with (BV) and without BV (nonBV) attending a family planning unit for first trimester abortion. The concentrations of IL-1beta, IL-6, TNF and FFN were determined by quantitative enzyme immunoassays. TNF was determined in 63 women (BV, n=25) out of whom 37 (BV, n=11) were analyzed for IL-1beta and the remaining 26 for IL-6 (BV, n=14). FFN was determined in another 36 women (BV, n= 19). The cytokine-inducing capacity of endotoxin-containing cervical mucus and purified endotoxin of Prevotella bivia were studied by an in vitro cell assay using a human monocytic cell line (THP-1).IL-lbeta and IL-6 were found in almost all women. The levels of IL-1beta, but not IL-6, TNF or FFN, were significantly increased in women with BV compared with the nonBV women (p<0.05). Purified endotoxin from P. bivia, and cervical mucus from BV women containing high levels of endotoxin were able to induce a cytokine response (IL-6) in monocytic cells in vitro.BV is associated with increased levels of IL-1beta in the lower genital tract of pregnant women in the first trimester. The ability of BV-associated endotoxins to induce cytokine production in monocytic cells may partly explain the increased IL-1beta levels. | |
650 | 7 | a NATURVETENSKAPx Biologix Immunologi0 (SwePub)106052 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Immunology0 (SwePub)106052 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Mikrobiologi inom det medicinska området0 (SwePub)301092 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Microbiology in the medical area0 (SwePub)301092 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reproduktionsmedicin och gynekologi0 (SwePub)302202 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Obstetrics, Gynaecology and Reproductive Medicine0 (SwePub)302202 hsv//eng |
653 | a Adult | |
653 | a Bacteroidaceae Infections | |
653 | a immunology | |
653 | a metabolism | |
653 | a microbiology | |
653 | a Cervix Mucus | |
653 | a metabolism | |
653 | a Endotoxins | |
653 | a metabolism | |
653 | a Female | |
653 | a Fibronectins | |
653 | a metabolism | |
653 | a Genitalia | |
653 | a Female | |
653 | a immunology | |
653 | a metabolism | |
653 | a microbiology | |
653 | a Humans | |
653 | a Interleukin-1 | |
653 | a metabolism | |
653 | a Interleukin-6 | |
653 | a metabolism | |
653 | a Pregnancy | |
653 | a Pregnancy Complications | |
653 | a Infectious | |
653 | a immunology | |
653 | a metabolism | |
653 | a microbiology | |
653 | a Pregnancy Trimester | |
653 | a First | |
653 | a Prevotella | |
653 | a Tumor Necrosis Factor-alpha | |
653 | a metabolism | |
653 | a Vaginosis | |
653 | a Bacterial | |
653 | a immunology | |
653 | a metabolism | |
653 | a microbiology | |
700 | 1 | a Platz-Christensen, Jens Jörgenu Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för obstetrik och gynekologi,Institute for the Health of Women and Children, Dept of Obstetrics and Gynaecology4 aut |
700 | 1 | a Hosseini Johnsson, Nosrat,d 1953u Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk bakteriologi,Institute of Laboratory Medicine, Dept of Clinical Bacteriology4 aut0 (Swepub:gu)xhosno |
700 | 1 | a Rosén, Petrau Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk bakteriologi,Institute of Laboratory Medicine, Dept of Clinical Bacteriology4 aut |
710 | 2 | a Göteborgs universitetb Institutionen för laboratoriemedicin, Avdelningen för klinisk bakteriologi4 org |
773 | 0 | t Acta obstetricia et gynecologica Scandinavicad : Wileyg 77:7, s. 701-6q 77:7<701-6x 0001-6349 |
856 | 4 8 | u https://gup.ub.gu.se/publication/289842 |
856 | 4 8 | u https://doi.org/10.1034/j.1600-0412.1998.770701.x |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.