Search: onr:"swepub:oai:gup.ub.gu.se/290424" >
Genome-wide associa...
Genome-wide association study of panic disorder reveals genetic overlap with neuroticism and depression
- Article/chapterEnglish2021
Publisher, publication year, extent ...
-
2019-11-11
-
Springer Science and Business Media LLC,2021
Numbers
-
LIBRIS-ID:oai:gup.ub.gu.se/290424
-
https://gup.ub.gu.se/publication/290424URI
-
https://doi.org/10.1038/s41380-019-0590-2DOI
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:148597643URI
Supplementary language notes
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Panic disorder (PD) has a lifetime prevalence of 2–4% and heritability estimates of 40%. The contributory genetic variants remain largely unknown, with few and inconsistent loci having been reported. The present report describes the largest genome-wide association study (GWAS) of PD to date comprising genome-wide genotype data of 2248 clinically well-characterized PD patients and 7992 ethnically matched controls. The samples originated from four European countries (Denmark, Estonia, Germany, and Sweden). Standard GWAS quality control procedures were conducted on each individual dataset, and imputation was performed using the 1000 Genomes Project reference panel. A meta-analysis was then performed using the Ricopili pipeline. No genome-wide significant locus was identified. Leave-one-out analyses generated highly significant polygenic risk scores (PRS) (explained variance of up to 2.6%). Linkage disequilibrium (LD) score regression analysis of the GWAS data showed that the estimated heritability for PD was 28.0–34.2%. After correction for multiple testing, a significant genetic correlation was found between PD and major depressive disorder, depressive symptoms, and neuroticism. A total of 255 single-nucleotide polymorphisms (SNPs) with p < 1 × 10−4 were followed up in an independent sample of 2408 PD patients and 228,470 controls from Denmark, Iceland and the Netherlands. In the combined analysis, SNP rs144783209 showed the strongest association with PD (pcomb = 3.10 × 10−7). Sign tests revealed a significant enrichment of SNPs with a discovery p-value of <0.0001 in the combined follow up cohort (p = 0.048). The present integrative analysis represents a major step towards the elucidation of the genetic susceptibility to PD. © 2019, The Author(s), under exclusive licence to Springer Nature Limited.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Awasthi, S.
(author)
-
Wolf, C.
(author)
-
Maron, E.
(author)
-
Erhardt, A.Karolinska Institutet
(author)
-
Czamara, D.
(author)
-
Eriksson, Elias,1956Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Neuroscience and Physiology, Department of Pharmacology(Swepub:gu)xereli
(author)
-
Lavebratt, C.Karolinska Institutet
(author)
-
Allgulander, C.
(author)
-
Friedrich, N.
(author)
-
Becker, J.
(author)
-
Hecker, J.
(author)
-
Rambau, S.
(author)
-
Conrad, R.Karolinska Institutet
(author)
-
Geiser, F.
(author)
-
McMahon, F. J.
(author)
-
Moebus, S.Karolinska Institutet
(author)
-
Hess, T.
(author)
-
Buerfent, B. C.
(author)
-
Hoffmann, P.
(author)
-
Herms, S.
(author)
-
Heilmann-Heimbach, S.
(author)
-
Kockum, I.Karolinska Institutet
(author)
-
Olsson, T.Karolinska Institutet
(author)
-
Alfredsson, L.Karolinska Institutet
(author)
-
Weber, H.
(author)
-
Alpers, G. W.
(author)
-
Arolt, V.
(author)
-
Fehm, L.
(author)
-
Fydrich, T.
(author)
-
Gerlach, A. L.
(author)
-
Hamm, A.
(author)
-
Kircher, T.
(author)
-
Pané-Farré, C. A.
(author)
-
Pauli, P.Karolinska Institutet
(author)
-
Rief, W.
(author)
-
Ströhle, A.
(author)
-
Plag, J.
(author)
-
Lang, T.
(author)
-
Wittchen, H. U.
(author)
-
Mattheisen, M.
(author)
-
Meier, S.
(author)
-
Metspalu, A.
(author)
-
Domschke, K.
(author)
-
Reif, A.
(author)
-
Hovatta, I.
(author)
-
Lindefors, N.Karolinska Institutet
(author)
-
Andersson, E.
(author)
-
Schalling, M.
(author)
-
Mbarek, H.
(author)
-
Milaneschi, Y.
(author)
-
de Geus, E. J. C.
(author)
-
Boomsma, D. I.
(author)
-
Penninx, B. W. J. H.
(author)
-
Thorgeirsson, T. E.
(author)
-
Steinberg, S.
(author)
-
Stefansson, K.
(author)
-
Stefansson, H.
(author)
-
Müller-Myhsok, B.
(author)
-
Hansen, T. F.
(author)
-
Børglum, A. D.
(author)
-
Werge, T.
(author)
-
Mortensen, P. B.
(author)
-
Nordentoft, M.
(author)
-
Hougaard, D. M.
(author)
-
Hultman, C. M.
(author)
-
Sullivan, P. F.
(author)
-
Nöthen, M. M.
(author)
-
Woldbye, D. P. D.
(author)
-
Mors, O.
(author)
-
Binder, E. B.
(author)
-
Rück, C.
(author)
-
Ripke, S.
(author)
-
Deckert, J.
(author)
-
Schumacher, J.
(author)
-
Karolinska InstitutetInstitutionen för neurovetenskap och fysiologi, sektionen för farmakologi
(creator_code:org_t)
Related titles
-
In:Molecular Psychiatry: Springer Science and Business Media LLC26, s. 4179-41901359-41841476-5578
Internet link
Find in a library
To the university's database
- By the author/editor
-
Forstner, A. J.
-
Awasthi, S.
-
Wolf, C.
-
Maron, E.
-
Erhardt, A.
-
Czamara, D.
-
show more...
-
Eriksson, Elias, ...
-
Lavebratt, C.
-
Allgulander, C.
-
Friedrich, N.
-
Becker, J.
-
Hecker, J.
-
Rambau, S.
-
Conrad, R.
-
Geiser, F.
-
McMahon, F. J.
-
Moebus, S.
-
Hess, T.
-
Buerfent, B. C.
-
Hoffmann, P.
-
Herms, S.
-
Heilmann-Heimbac ...
-
Kockum, I.
-
Olsson, T.
-
Alfredsson, L.
-
Weber, H.
-
Alpers, G. W.
-
Arolt, V.
-
Fehm, L.
-
Fydrich, T.
-
Gerlach, A. L.
-
Hamm, A.
-
Kircher, T.
-
Pané-Farré, C. A ...
-
Pauli, P.
-
Rief, W.
-
Ströhle, A.
-
Plag, J.
-
Lang, T.
-
Wittchen, H. U.
-
Mattheisen, M.
-
Meier, S.
-
Metspalu, A.
-
Domschke, K.
-
Reif, A.
-
Hovatta, I.
-
Lindefors, N.
-
Andersson, E.
-
Schalling, M.
-
Mbarek, H.
-
Milaneschi, Y.
-
de Geus, E. J. C ...
-
Boomsma, D. I.
-
Penninx, B. W. J ...
-
Thorgeirsson, T. ...
-
Steinberg, S.
-
Stefansson, K.
-
Stefansson, H.
-
Müller-Myhsok, B ...
-
Hansen, T. F.
-
Børglum, A. D.
-
Werge, T.
-
Mortensen, P. B.
-
Nordentoft, M.
-
Hougaard, D. M.
-
Hultman, C. M.
-
Sullivan, P. F.
-
Nöthen, M. M.
-
Woldbye, D. P. D ...
-
Mors, O.
-
Binder, E. B.
-
Rück, C.
-
Ripke, S.
-
Deckert, J.
-
Schumacher, J.
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Psychiatry
- Articles in the publication
-
Molecular Psychi ...
- By the university
-
University of Gothenburg
-
Karolinska Institutet