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Elevated levels of ...
Elevated levels of IL-6 and IGFBP-1 predict low serum IGF-1 levels during continuous infusion of rhIGF-1/rhIGFBP-3 in extremely preterm infants
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- Klevebro, S. (author)
- Karolinska Institutet,Karolinska Institute
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- Hellgren, Gunnel, 1961 (author)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institutionen för neurovetenskap och fysiologi,Institute of Biomedicine,Institute of Neuroscience and Physiology
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- Hansen-Pupp, Ingrid (author)
- Lund University,Lunds universitet,Neonatalogi,Forskargrupper vid Lunds universitet,Neonatology,Lund University Research Groups,Skåne University Hospital
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- Wackernagel, D. (author)
- Karolinska Institutet,Karolinska Institute
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- Hallberg, B. (author)
- Karolinska Institutet,Karolinska Institute
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- Borg, J. (author)
- Premacure AB
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- Pivodic, A. (author)
- Statistiska Konsultgruppen
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- Smith, L. (author)
- Boston Children's Hospital,Harvard University
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- Ley, David (author)
- Lund University,Lunds universitet,Neonatalogi,Forskargrupper vid Lunds universitet,Neonatology,Lund University Research Groups,Skåne University Hospital
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- Hellström, Ann, 1959 (author)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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(creator_code:org_t)
- Elsevier BV, 2020
- 2020
- English.
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In: Growth Hormone and IGF Research. - : Elsevier BV. - 1096-6374. ; 50, s. 1-8
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Abstract
Subject headings
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- Objective: Steady state insulin-like growth factor-1 (IGF-1) levels vary significantly during continuous intravenous infusion of recombinant human insulin-like growth factor-1/recombinant human insulin-like growth factor binding protein-3 (rhIGF-1/rhIGFBP-3) in the first weeks of life in extremely preterm infants. We evaluated interleukin-6 (IL-6) and insulin-like growth factor binding protein-1 (IGFBP-1) levels as predictors of low IGF-1 levels. Methods: Nineteen extremely preterm infants were enrolled in a trial, 9 received rhIGF-1/rhIGFBP-3 and 10 received standard neonatal care. Blood samples were analyzed daily for IGF-1, IL-6 and IGFBP-1 during intervention with rhIGF-1/rhIGFBP-3. Results: Thirty seven percent of IGF-1 values during active treatment were <20 μg/L. Among treated infants, higher levels of IL-6, one and two days before sampled IGF-1, were associated with IGF-1 < 20 μg/L, gestational age adjusted OR 1.30 (95% CI 1.03–1.63), p = .026, and 1.57 (95% CI 1.26–1.97), p < .001 respectively. Higher levels of IGFBP-1 one day before sampled IGF-1 was also associated with IGF-1 < 20 μg/L, gestational age adjusted OR 1.74 (95% CI 1.19–2.53), p = .004. Conclusion: In preterm infants receiving continuous infusion of rhIGF-1/rhIGFBP-3, higher levels of IL-6 and IGFBP-1 preceded lower levels of circulating IGF-1. These findings demonstrate a need to further evaluate if inflammation and/or infection suppress serum IGF-1 levels. The trial is registered at ClinicalTrials.gov (NCT01096784). © 2019
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Keyword
- IGF-1
- IGFBP-1
- IL-6
- Inflammation
- Preterm infants
- rhIGF-1/rhIGFBP-3
- interleukin 6
- mecasermin rinfabate
- somatomedin binding protein 1
- somatomedin C
- Article
- blood analysis
- clinical article
- continuous infusion
- controlled study
- disease association
- female
- gestational age
- human
- infection
- male
- newborn
- newborn care
- prediction
- prematurity
- priority journal
- protein blood level
- randomized controlled trial
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Klevebro, S.
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Hellgren, Gunnel ...
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Hansen-Pupp, Ing ...
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Wackernagel, D.
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Hallberg, B.
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Borg, J.
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show more...
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Pivodic, A.
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Smith, L.
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Ley, David
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Hellström, Ann, ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Pediatrics
- Articles in the publication
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Growth Hormone a ...
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Growth hormone & ...
- By the university
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University of Gothenburg
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Lund University
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Karolinska Institutet