Search: onr:"swepub:oai:gup.ub.gu.se/290861" >
Interleukin-22-medi...
Interleukin-22-mediated host glycosylation prevents Clostridioides difficile infection by modulating the metabolic activity of the gut microbiota
-
Nagao-Kitamoto, H. (author)
-
Leslie, J. L. (author)
-
Kitamoto, S. (author)
-
show more...
-
- Jin, Chunsheng (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
-
- Thomsson, Kristina A, 1969 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
-
Gillilland, M. G. (author)
-
Kuffa, P. (author)
-
Goto, Y. (author)
-
Jenq, R. R. (author)
-
Ishii, C. (author)
-
Hirayama, A. (author)
-
Seekatz, A. M. (author)
-
Martens, E. C. (author)
-
Eaton, K. A. (author)
-
Kao, J. Y. (author)
-
Fukuda, S. (author)
-
Higgins, P. D. R. (author)
-
- Karlsson, Niclas G., 1966 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
-
Young, V. B. (author)
-
Kamada, N. (author)
-
show less...
-
(creator_code:org_t)
- 2020-02-17
- 2020
- English.
-
In: Nature Medicine. - : Springer Science and Business Media LLC. - 1078-8956 .- 1546-170X. ; 26, s. 608-617
- Related links:
-
https://www.ncbi.nlm...
-
show more...
-
https://gup.ub.gu.se...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- In germ-free mice colonized with human microbiota, mucosal IL-22 signaling promotes the growth of succinate-consuming commensal bacteria via host mucus glycosylation, and transplantation of these bacteria limits Clostridioides difficile infection. The involvement of host immunity in the gut microbiota-mediated colonization resistance to Clostridioides difficile infection (CDI) is incompletely understood. Here, we show that interleukin (IL)-22, induced by colonization of the gut microbiota, is crucial for the prevention of CDI in human microbiota-associated (HMA) mice. IL-22 signaling in HMA mice regulated host glycosylation, which enabled the growth of succinate-consuming bacteria Phascolarctobacterium spp. within the gut microbiome. Phascolarctobacterium reduced the availability of luminal succinate, a crucial metabolite for the growth of C. difficile, and therefore prevented the growth of C. difficile. IL-22-mediated host N-glycosylation is likely impaired in patients with ulcerative colitis (UC) and renders UC-HMA mice more susceptible to CDI. Transplantation of healthy human-derived microbiota or Phascolarctobacterium reduced luminal succinate levels and restored colonization resistance in UC-HMA mice. IL-22-mediated host glycosylation thus fosters the growth of commensal bacteria that compete with C. difficile for the nutritional niche.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- germ-free mice
- ulcerative-colitis
- il-22
- colonization
- resistance
- cells
- transplantation
- fucosylation
- suppressor
- adhesion
- Biochemistry & Molecular Biology
- Cell Biology
- Research & Experimental
- Medicine
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Nagao-Kitamoto, ...
-
Leslie, J. L.
-
Kitamoto, S.
-
Jin, Chunsheng
-
Thomsson, Kristi ...
-
Gillilland, M. G ...
-
show more...
-
Kuffa, P.
-
Goto, Y.
-
Jenq, R. R.
-
Ishii, C.
-
Hirayama, A.
-
Seekatz, A. M.
-
Martens, E. C.
-
Eaton, K. A.
-
Kao, J. Y.
-
Fukuda, S.
-
Higgins, P. D. R ...
-
Karlsson, Niclas ...
-
Young, V. B.
-
Kamada, N.
-
show less...
- About the subject
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Biological Scien ...
-
and Biochemistry and ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Cell and Molecul ...
- Articles in the publication
-
Nature Medicine
- By the university
-
University of Gothenburg