A decade of FRAX: how has it changed the management of osteoporosis?

The fracture risk assessment tool, FRAX(R), was released in 2008 and provides country-specific algorithms for estimating individualized 10-year probability of hip and major osteoporotic fracture (hip, clinical spine, distal forearm, and proximal humerus). Since its release, 71 models have been made available for 66 countries covering more than 80% of the world population. The website receives approximately 3 million visits annually. Following independent validation, FRAX has been incorporated into more than 80 guidelines worldwide. The application of FRAX in assessment guidelines has been heterogeneous with the adoption of several different approaches in setting intervention thresholds. Whereas most guidelines adopt a case-finding strategy, the case for FRAX-based community screening in the elderly is increasing. The relationship between FRAX and efficacy of intervention has been explored and is expected to influence treatment guidelines in the future.

MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Health Sciences Public Health, Global Health, Social Medicine and Epidemiology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Ortopedi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Orthopaedics hsv//eng
FRAX
Fracture probability
Clinical risk factors
Intervention
thresholds
Risk assessment
Screening
fracture risk-assessment
postmenopausal women
intervention thresholds
cost-effectiveness
hip fracture
official positions
screening-program
clinician guide
bone-density
double-blind
Geriatrics & Gerontology

Harvey, N. C. (author)
Johansson, H. (author)
Liu, E. W. (author)
Vandenput, Liesbeth,1974Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition(Swepub:gu)xvanli (author)
Lorentzon, Mattias,1970Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition(Swepub:gu)xlomat (author)
Leslie, W. D. (author)
McCloskey, E. V. (author)
Göteborgs universitetCentre for Bone and Arthritis Research (creator_code:org_t)

In:Aging Clinical and Experimental Research: Springer Science and Business Media LLC32:2, s. 187-1961594-06671720-8319

By the author/editor: Kanis, J. A.; Harvey, N. C.; Johansson, H.; Liu, E. W.; Vandenput, Liesb ...; Lorentzon, Matti ...; show more...; Leslie, W. D.; McCloskey, E. V.; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences; and Public Health Gl ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Orthopaedics

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