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A Crucial Role for ...
A Crucial Role for Diet in the Relationship Between Gut Microbiota and Cardiometabolic Disease
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Attaye, I. (author)
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Pinto-Sietsma, S. J. (author)
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Herrema, H. (author)
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- Nieuwdorp, Max (author)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory
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(creator_code:org_t)
- Annual Reviews, 2020
- 2020
- English.
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In: Annual Review of Medicine. - : Annual Reviews. - 0066-4219 .- 1545-326X. - 9780824305710 ; , s. 149-161
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Abstract
Subject headings
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- Cardiometabolic disease (CMD), such as type 2 diabetes mellitus and cardiovascular disease, contributes significantly tomorbidity and mortality on a global scale. The gut microbiota has emerged as a potential target to beneficially modulate CMD risk, possibly via dietary interventions. Dietary interventions have been shown to considerably alter gut microbiota composition and function. Moreover, several diet-derived microbial metabolites are able to modulate human metabolism and thereby alter CMD risk. Dietary interventions that affect gut microbiota composition and function are therefore a promising, novel, and cost-efficient method to reduce CMD risk. Studies suggest that fermentable carbohydrates can beneficially alter gut microbiota composition and function, whereas high animal protein and high fat intake negatively impact gut microbiota function and composition. This review focuses on the role of macronutrients (i.e., carbohydrate, protein, and fat) and dietary patterns (e.g., vegetarian/vegan and Mediterranean diet) in gut microbiota composition and function in the context of CMD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences (hsv//eng)
Keyword
- gut microbiota
- cardiometabolic disease
- diet
- dietary pattern
- medium-chain triglycerides
- cardiovascular-disease
- weight-loss
- intestinal microbiota
- insulin sensitivity
- induced obesity
- metaanalysis
- mortality
- health
- impact
Publication and Content Type
- ref (subject category)
- kap (subject category)
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