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C-11 PBR28 MR-PET i...
C-11 PBR28 MR-PET imaging reveals lower regional brain expression of translocator protein (TSPO) in young adult males with autism spectrum disorder
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Zurcher, N. R. (author)
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Loggia, M. L. (author)
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Mullett, J. E. (author)
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Tseng, C. (author)
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Bhanot, A. (author)
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Richey, L. (author)
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Hightower, B. G. (author)
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Wu, C. (author)
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Parmar, A. J. (author)
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Butterfield, R. I. (author)
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Dubois, J. M. (author)
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Chonde, D. B. (author)
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Izquierdo-Garcia, D. (author)
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Wey, H. Y. (author)
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Catana, C. (author)
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- Hadjikhani, Nouchine, 1966 (author)
- Gothenburg University,Göteborgs universitet,Gillbergcentrum,Gillberg Neuropsychiatry Centre
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McDougle, C. J. (author)
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Hooker, J. M. (author)
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(creator_code:org_t)
- 2020-02-19
- 2021
- English.
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In: Molecular Psychiatry. - : Springer Science and Business Media LLC. - 1359-4184 .- 1476-5578.
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https://www.nature.c...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Mechanisms of neuroimmune and mitochondrial dysfunction have been repeatedly implicated in autism spectrum disorder (ASD). To examine these mechanisms in ASD individuals, we measured the in vivo expression of the 18 kDa translocator protein (TSPO), an activated glial marker expressed on mitochondrial membranes. Participants underwent scanning on a simultaneous magnetic resonance-positron emission tomography (MR-PET) scanner with the second-generation TSPO radiotracer [C-11]PBR28. By comparing TSPO in 15 young adult males with ASD with 18 age- and sex-matched controls, we showed that individuals with ASD exhibited lower regional TSPO expression in several brain regions, including the bilateral insular cortex, bilateral precuneus/posterior cingulate cortex, and bilateral temporal, angular, and supramarginal gyri, which have previously been implicated in autism in functional MR imaging studies. No brain region exhibited higher regional TSPO expression in the ASD group compared with the control group. A subset of participants underwent a second MR-PET scan after a median interscan interval of 3.6 months, and we determined that TSPO expression over this period of time was stable and replicable. Furthermore, voxelwise analysis confirmed lower regional TSPO expression in ASD at this later time point. Lower TSPO expression in ASD could reflect abnormalities in neuroimmune processes or mitochondrial dysfunction.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Keyword
- 18 kda
- microglial activation
- glial activation
- temporal-lobe
- 1st-episode psychosis
- neuroinflammation
- children
- binding
- risk
- schizophrenia
- Biochemistry & Molecular Biology
- Neurosciences & Neurology
- Psychiatry
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Zurcher, N. R.
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Loggia, M. L.
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Mullett, J. E.
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Tseng, C.
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Bhanot, A.
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Richey, L.
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show more...
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Hightower, B. G.
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Wu, C.
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Parmar, A. J.
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Butterfield, R. ...
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Dubois, J. M.
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Chonde, D. B.
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Izquierdo-Garcia ...
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Wey, H. Y.
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Catana, C.
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Hadjikhani, Nouc ...
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McDougle, C. J.
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Hooker, J. M.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
- Articles in the publication
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Molecular Psychi ...
- By the university
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University of Gothenburg