Search: onr:"swepub:oai:gup.ub.gu.se/291611" >
Biomarker for weldi...
Biomarker for welding exposure in exhaled endogenous particles
-
- Ljungqvist, Göran (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine
-
- Bredberg, Anna (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine
-
- Taube, Fabian, 1967 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa, enheten för arbets-och miljömedicin,Institute of Medicine, Department of Public Health and Community Medicine, Section of Occupational and environmental medicine
-
show more...
-
- Ljungström, Evert, 1949 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
-
- Larsson, Per (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine
-
Mirogorodskaya, Ekaterina (author)
-
Isaxon, Christina (author)
-
- Forsgard, Niklas (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin,Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine
-
Löndahl, Jakob (author)
-
- Olin, Anna-Carin, 1960 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa, enheten för arbets-och miljömedicin,Institute of Medicine, Department of Public Health and Community Medicine, Section of Occupational and environmental medicine
-
show less...
-
(creator_code:org_t)
- 2014
- 2014
- English.
-
In: The European respiratory journal. Supplement. - 0904-1850.
- Related links:
-
https://gup.ub.gu.se...
Abstract
Subject headings
Close
- More than two million workers are exposed to pneumotoxic welding aerosols and there is a need for target organ specific biomarkers of exposure. Manganese is a common constituent of iron alloys, its occupational exposure limit is low and other biomarkers are poor, which makes it a good model substance. We hypothesize that metal particles are deposited in the small airways and are incorporated into endogenous particles formed during respiration. A subsequent analysis of these particles in exhaled air (PEx) can serve as a biomarker for metals in welding fumes. We have recently developed a method for the collection of PEx (Almstrand, A.-C. et al. Anal Chem 2008; 81:662-668), based on counting of the exhaled particles and subsequent collection by impaction on a filter. Here we developed a method for analysis of trace metal content, i.e. manganese and iron in PEx. The method involved desorption of the filter in 5% nitric acid and analysis of the metal content by ICP-MS. To test our hypothesis, we exposed 9 healthy non-smokers (4F/5M, 29-63 years) to welding aerosol in an exposure chamber (Isaxon, C. et al. Aerosol Sci Tech 2012; 47:52-59) for two hours. Manganese and iron was analysed in PEx samples collected before, immediately after and 24 h after exposure. The results showed that 4 out of 9 persons had substantially increased levels of both manganese and iron in PEx immediately after exposure. Before exposure two samples had an iron content above limit of detection and none of the samples collected after 24 h. Manganese was below LOD in all samples collected before and 24 h after exposure. The study showed that the analysis of metals in PEx is a promising biomarker for metal aerosol exposure.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
- NATURVETENSKAP -- Kemi -- Analytisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Analytical Chemistry (hsv//eng)
Publication and Content Type
- ref (subject category)
- kon (subject category)
Find in a library
To the university's database
- By the author/editor
-
Ljungqvist, Göra ...
-
Bredberg, Anna
-
Taube, Fabian, 1 ...
-
Ljungström, Ever ...
-
Larsson, Per
-
Mirogorodskaya, ...
-
show more...
-
Isaxon, Christin ...
-
Forsgard, Niklas
-
Löndahl, Jakob
-
Olin, Anna-Carin ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Health Sciences
-
and Occupational Hea ...
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Chemical Science ...
-
and Analytical Chemi ...
- Articles in the publication
-
The European res ...
- By the university
-
University of Gothenburg