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An atlas of human m...
An atlas of human metabolism
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- Robinson, Jonathan, 1986 (author)
- Chalmers tekniska högskola,Chalmers University of Technology,Chalmers Univ Technol, Dept Biol & Biol Engn, Kemivagen 10, SE-41258 Gothenburg, Sweden.;Chalmers Univ Technol, Wallenberg Ctr Prot Res, Kemivagen 10, SE-41258 Gothenburg, Sweden.
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- Kocabas, Pinar, 1980 (author)
- Chalmers tekniska högskola,Chalmers University of Technology,Chalmers Univ Technol, Dept Biol & Biol Engn, Kemivagen 10, SE-41258 Gothenburg, Sweden.;Chalmers Univ Technol, Wallenberg Ctr Prot Res, Kemivagen 10, SE-41258 Gothenburg, Sweden.
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- Wang, Hao (author)
- Gothenburg University,Göteborgs universitet,Wallenberg Centre for Molecular and Translational Medicine,University of Gothenburg,Chalmers tekniska högskola,Chalmers University of Technology,Chalmers Univ Technol, Dept Biol & Biol Engn, Kemivagen 10, SE-41258 Gothenburg, Sweden.;Univ Gothenburg, Wallenberg Ctr Mol & Translat Med, Kemivagen 10, SE-41258 Gothenburg, Sweden.;Chalmers Univ Technol, Sci Life Lab, Natl Bioinformat Infrastruct Sweden, Dept Biol & Biol Engn, Kemivagen 10, SE-41258 Gothenburg, Sweden.
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- Cholley, Pierre-Etienne, 1984 (author)
- Chalmers tekniska högskola,Chalmers University of Technology,Chalmers Univ Technol, Sci Life Lab, Natl Bioinformat Infrastruct Sweden, Dept Biol & Biol Engn, Kemivagen 10, SE-41258 Gothenburg, Sweden.
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- Cook, Daniel John, 1986 (author)
- Chalmers tekniska högskola,Chalmers University of Technology,Chalmers Univ Technol, Dept Biol & Biol Engn, Kemivagen 10, SE-41258 Gothenburg, Sweden.
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- Nilsson, Avlant, 1985 (author)
- Chalmers tekniska högskola,Chalmers University of Technology,Chalmers Univ Technol, Dept Biol & Biol Engn, Kemivagen 10, SE-41258 Gothenburg, Sweden.
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- Anton, Petre Mihail, 1989 (author)
- Chalmers tekniska högskola,Chalmers University of Technology,Chalmers Univ Technol, Sci Life Lab, Natl Bioinformat Infrastruct Sweden, Dept Biol & Biol Engn, Kemivagen 10, SE-41258 Gothenburg, Sweden.
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- Ferreira, Raphael, 1990 (author)
- Chalmers tekniska högskola,Chalmers University of Technology,Chalmers Univ Technol, Dept Biol & Biol Engn, Kemivagen 10, SE-41258 Gothenburg, Sweden.
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- Domenzain Del Castillo Cerecer, Iván, 1991 (author)
- Chalmers tekniska högskola,Chalmers University of Technology,Chalmers Univ Technol, Dept Biol & Biol Engn, Kemivagen 10, SE-41258 Gothenburg, Sweden.;Chalmers Univ Technol, Wallenberg Ctr Prot Res, Kemivagen 10, SE-41258 Gothenburg, Sweden.
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- Billa, Virinchi, 1994 (author)
- Chalmers tekniska högskola,Chalmers University of Technology,Chalmers Univ Technol, Dept Biol & Biol Engn, Kemivagen 10, SE-41258 Gothenburg, Sweden.
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- Limeta, Angelo, 1996 (author)
- Chalmers tekniska högskola,Chalmers University of Technology,Chalmers Univ Technol, Dept Biol & Biol Engn, Kemivagen 10, SE-41258 Gothenburg, Sweden.
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- Hedin, Alex, 1994 (author)
- Chalmers tekniska högskola,Chalmers University of Technology,Chalmers Univ Technol, Dept Biol & Biol Engn, Kemivagen 10, SE-41258 Gothenburg, Sweden.
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- Gustafsson, Johan, 1976 (author)
- Chalmers tekniska högskola,Chalmers University of Technology,Chalmers Univ Technol, Dept Biol & Biol Engn, Kemivagen 10, SE-41258 Gothenburg, Sweden.;Chalmers Univ Technol, Wallenberg Ctr Prot Res, Kemivagen 10, SE-41258 Gothenburg, Sweden.
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- Kerkhoven, Eduard, 1985 (author)
- Chalmers tekniska högskola,Chalmers University of Technology,Chalmers Univ Technol, Dept Biol & Biol Engn, Kemivagen 10, SE-41258 Gothenburg, Sweden.
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- Svensson, Thomas, 1963 (author)
- Karolinska Institutet
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- Palsson, B. O. (author)
- University of California,Danmarks Tekniske Universitet,Technical University of Denmark,Tech Univ Denmark, Novo Nordisk Fdn, Ctr Biosustainabil, DK-2800 Lyngby, Denmark.;Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA.;Univ Calif San Diego, Dept Pediat, La Jolla, CA 92093 USA.
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- Mardinoglu, Adil (author)
- KTH,Science for Life Laboratory, SciLifeLab,Systembiologi,Kings Coll London, Fac Dent Oral & Craniofacial Sci, Ctr Host Microbiome Interact, London WC2R 2LS, England.
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- Hansson, Lena, 1979 (author)
- Chalmers tekniska högskola,Chalmers University of Technology,Chalmers Univ Technol, Sci Life Lab, Natl Bioinformat Infrastruct Sweden, Dept Biol & Biol Engn, Kemivagen 10, SE-41258 Gothenburg, Sweden.;Novo Nordisk Res Ctr Oxford, Oxford OX3 7FZ, England.
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- Uhlén, Mathias (author)
- KTH,Science for Life Laboratory, SciLifeLab,Proteinvetenskap,Wallenberg Center for Protein Research,Tech Univ Denmark, Novo Nordisk Fdn, Ctr Biosustainabil, DK-2800 Lyngby, Denmark.
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- Nielsen, Jens B, 1962 (author)
- Chalmers tekniska högskola,Chalmers University of Technology,Danmarks Tekniske Universitet,Technical University of Denmark,BioInnovation Institute (BII),Chalmers Univ Technol, Dept Biol & Biol Engn, Kemivagen 10, SE-41258 Gothenburg, Sweden.;Chalmers Univ Technol, Wallenberg Ctr Prot Res, Kemivagen 10, SE-41258 Gothenburg, Sweden.;Tech Univ Denmark, Novo Nordisk Fdn, Ctr Biosustainabil, DK-2800 Lyngby, Denmark.;BioInnovat Inst, Ole Maaloes Vej 3, DK-2200 Copenhagen, Denmark.
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Chalmers tekniska högskola Chalmers Univ Technol, Dept Biol & Biol Engn, Kemivagen 10, SE-41258 Gothenburg, Sweden;Chalmers Univ Technol, Wallenberg Ctr Prot Res, Kemivagen 10, SE-41258 Gothenburg, Sweden. (creator_code:org_t)
- American Association for the Advancement of Science (AAAS), 2020
- 2020
- English.
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In: Science Signaling. - : American Association for the Advancement of Science (AAAS). - 1945-0877 .- 1937-9145. ; 13:624
- Related links:
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https://doi.org/10.1...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://research.cha...
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https://research.cha...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Subject headings
Close
- Genome-scale metabolic models (GEMs) are valuable tools to study metabolism and provide a scaffold for the integrative analysis of omics data. Researchers have developed increasingly comprehensive human GEMs, but the disconnect among different model sources and versions impedes further progress. We therefore integrated and extensively curated the most recent human metabolic models to construct a consensus GEM, Human1. We demonstrated the versatility of Human1 through the generation and analysis of cell- and tissue-specific models using transcriptomic, proteomic, and kinetic data. We also present an accompanying web portal, Metabolic Atlas (https://www.metabolicatlas.org/), which facilitates further exploration and visualization of Human1 content. Human1 was created using a version-controlled, open-source model development framework to enable community-driven curation and refinement. This framework allows Human1 to be an evolving shared resource for future studies of human health and disease.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- NATURVETENSKAP -- Data- och informationsvetenskap -- Annan data- och informationsvetenskap (hsv//swe)
- NATURAL SCIENCES -- Computer and Information Sciences -- Other Computer and Information Science (hsv//eng)
- NATURVETENSKAP -- Data- och informationsvetenskap -- Bioinformatik (hsv//swe)
- NATURAL SCIENCES -- Computer and Information Sciences -- Bioinformatics (hsv//eng)
- NATURVETENSKAP -- Biologi -- Bioinformatik och systembiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Bioinformatics and Systems Biology (hsv//eng)
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
- NATURVETENSKAP -- Data- och informationsvetenskap -- Programvaruteknik (hsv//swe)
- NATURAL SCIENCES -- Computer and Information Sciences -- Software Engineering (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- fatty-acid-metabolism
- global reconstruction
- expression
- models
- target
- Biochemistry & Molecular Biology
- Cell Biology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Robinson, Jonath ...
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Kocabas, Pinar, ...
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Wang, Hao
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Cholley, Pierre- ...
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Cook, Daniel Joh ...
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Nilsson, Avlant, ...
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Anton, Petre Mih ...
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Ferreira, Raphae ...
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Domenzain Del Ca ...
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Billa, Virinchi, ...
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Limeta, Angelo, ...
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Hedin, Alex, 199 ...
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Gustafsson, Joha ...
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Kerkhoven, Eduar ...
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Svensson, Thomas ...
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Palsson, B. O.
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Mardinoglu, Adil
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Hansson, Lena, 1 ...
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Uhlén, Mathias
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Nielsen, Jens B, ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Computer and Inf ...
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and Other Computer a ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Computer and Inf ...
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and Bioinformatics
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Bioinformatics a ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Computer and Inf ...
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and Software Enginee ...
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MEDICAL AND HEAL ...
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- Articles in the publication
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Science Signalin ...
- By the university
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University of Gothenburg
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Chalmers University of Technology
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Royal Institute of Technology
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Karolinska Institutet